FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 353:1793-1801 October 27, 2005 Number 17 Next

	Full Text PDF PDA Full Text Supplementary Material Perspective by Chen, C.-Z. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article

ABSTRACT

Background MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL.

Methods We evaluated the microRNA expression profiles of 94 samples of CLL cells for which the level of expression of 70-kD zeta-associated protein (ZAP-70), the mutational status of the rearranged immunoglobulin heavy-chain variable-region (IgV_H) gene, and the time from diagnosis to initial treatment were known. We also investigated the genomic sequence of 42 microRNA genes to identify abnormalities.

Results A unique microRNA expression signature composed of 13 genes (of 190 analyzed) differentiated cases of CLL with low levels of ZAP-70 expression from those with high levels and cases with unmutated IgV_H from those with mutated IgV_H. The same microRNA signature was also associated with the presence or absence of disease progression. We also identified a germ-line mutation in the miR-16-1–miR-15a primary precursor, which caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele. Germ-line or somatic mutations were found in 5 of 42 sequenced microRNAs in 11 of 75 patients with CLL, but no such mutations were found in 160 subjects without cancer (P<0.001).

Conclusions A unique microRNA signature is associated with prognostic factors and disease progression in CLL. Mutations in microRNA transcripts are common and may have functional importance.

Source Information

From the Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus (G.A.C., A.C., G.D.L., M.S., S.E.W., M.V.I., R.V., N.I.S., M.F., R.I., T.P., F.P., C.R., H.A., S.V., C.L., C.M.C.); the Department of Experimental and Diagnostic Medicine, Interdepartment Center for Cancer Research, University of Ferrara, Ferrara, Italy (M.F., M.N.); the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia (R.G., C.S.); and the Department of Medicine, University of California, San Diego, La Jolla (L.R., T.J.K.).

Address reprint requests to Dr. Croce at Ohio State University, Comprehensive Cancer Center, Wiseman Hall, Rm. 385K, 400 12th Ave., Columbus, OH 43210, or at carlo.croce{at}osumc.edu.

Full Text of this Article

This article has been cited by other articles:

• Chen, R. W., Bemis, L. T., Amato, C. M., Myint, H., Tran, H., Birks, D. K., Eckhardt, S. G., Robinson, W. A. (2008). Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma. Blood 112: 822-829 [Abstract] [Full Text]  
• Bruchova, H., Merkerova, M., Prchal, J. T. (2008). Aberrant expression of microRNA in polycythemia vera. haematol 93: 1009-1016 [Abstract] [Full Text]  
• Langer, C., Radmacher, M. D., Ruppert, A. S., Whitman, S. P., Paschka, P., Mrozek, K., Baldus, C. D., Vukosavljevic, T., Liu, C.-G., Ross, M. E., Powell, B. L., de la Chapelle, A., Kolitz, J. E., Larson, R. A., Marcucci, G., Bloomfield, C. D. (2008). High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study. Blood 111: 5371-5379 [Abstract] [Full Text]  
• Jongen-Lavrencic, M., Sun, S. M., Dijkstra, M. K., Valk, P. J. M., Lowenberg, B. (2008). MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 111: 5078-5085 [Abstract] [Full Text]  
• Zhang, L., Volinia, S., Bonome, T., Calin, G. A., Greshock, J., Yang, N., Liu, C.-G., Giannakakis, A., Alexiou, P., Hasegawa, K., Johnstone, C. N., Megraw, M. S., Adams, S., Lassus, H., Huang, J., Kaur, S., Liang, S., Sethupathy, P., Leminen, A., Simossis, V. A., Sandaltzopoulos, R., Naomoto, Y., Katsaros, D., Gimotty, P. A., DeMichele, A., Huang, Q., Butzow, R., Rustgi, A. K., Weber, B. L., Birrer, M. J., Hatzigeorgiou, A. G., Croce, C. M., Coukos, G. (2008). Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc. Natl. Acad. Sci. USA 105: 7004-7009 [Abstract] [Full Text]  
• Hackanson, B., Bennett, K. L., Brena, R. M., Jiang, J., Claus, R., Chen, S.-S., Blagitko-Dorfs, N., Maharry, K., Whitman, S. P., Schmittgen, T. D., Lubbert, M., Marcucci, G., Bloomfield, C. D., Plass, C. (2008). Epigenetic Modification of CCAAT/Enhancer Binding Protein {alpha} Expression in Acute Myeloid Leukemia. Cancer Res. 68: 3142-3151 [Abstract] [Full Text]  
• Marcucci, G., Radmacher, M. D., Maharry, K., Mrozek, K., Ruppert, A. S., Paschka, P., Vukosavljevic, T., Whitman, S. P., Baldus, C. D., Langer, C., Liu, C.-G., Carroll, A. J., Powell, B. L., Garzon, R., Croce, C. M., Kolitz, J. E., Caligiuri, M. A., Larson, R. A., Bloomfield, C. D. (2008). MicroRNA Expression in Cytogenetically Normal Acute Myeloid Leukemia. NEJM 358: 1919-1928 [Abstract] [Full Text]  
• Nikiforova, M. N., Tseng, G. C., Steward, D., Diorio, D., Nikiforov, Y. E. (2008). MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility. J. Clin. Endocrinol. Metab. 93: 1600-1608 [Abstract] [Full Text]  
• Doleshal, M., Magotra, A. A., Choudhury, B., Cannon, B. D., Labourier, E., Szafranska, A. E. (2008). Evaluation and Validation of Total RNA Extraction Methods for MicroRNA Expression Analyses in Formalin-Fixed, Paraffin-Embedded Tissues. J. Mol. Diagn. 10: 203-211 [Abstract] [Full Text]  
• Lee, J.-W., Choi, C. H., Choi, J.-J., Park, Y.-A., Kim, S.-J., Hwang, S. Y., Kim, W. Y., Kim, T.-J., Lee, J.-H., Kim, B.-G., Bae, D.-S. (2008). Altered MicroRNA Expression in Cervical Carcinomas. Clin. Cancer Res. 14: 2535-2542 [Abstract] [Full Text]  
• Nam, E. J., Yoon, H., Kim, S. W., Kim, H., Kim, Y. T., Kim, J. H., Kim, J. W., Kim, S. (2008). MicroRNA Expression Profiles in Serous Ovarian Carcinoma. Clin. Cancer Res. 14: 2690-2695 [Abstract] [Full Text]  
• Sander, S., Bullinger, L., Leupolt, E., Benner, A., Kienle, D., Katzenberger, T., Kalla, J., Ott, G., Muller-Hermelink, H. K., Barth, T. F.E., Moller, P., Lichter, P., Dohner, H., Stilgenbauer, S. (2008). Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations. haematol 93: 680-687 [Abstract] [Full Text]  
• Zhang, C. (2008). MicroRNomics: a newly emerging approach for disease biology. Physiol. Genomics 33: 139-147 [Abstract] [Full Text]  
• Calin, G. A., Cimmino, A., Fabbri, M., Ferracin, M., Wojcik, S. E., Shimizu, M., Taccioli, C., Zanesi, N., Garzon, R., Aqeilan, R. I., Alder, H., Volinia, S., Rassenti, L., Liu, X., Liu, C.-g., Kipps, T. J., Negrini, M., Croce, C. M. (2008). MiR-15a and miR-16-1 cluster functions in human leukemia. Proc. Natl. Acad. Sci. USA 105: 5166-5171 [Abstract] [Full Text]  
• Duhamel, M., Arrouss, I., Merle-Beral, H., Rebollo, A. (2008). The Aiolos transcription factor is up-regulated in chronic lymphocytic leukemia. Blood 111: 3225-3228 [Abstract] [Full Text]  
• Garzon, R., Volinia, S., Liu, C.-G., Fernandez-Cymering, C., Palumbo, T., Pichiorri, F., Fabbri, M., Coombes, K., Alder, H., Nakamura, T., Flomenberg, N., Marcucci, G., Calin, G. A., Kornblau, S. M., Kantarjian, H., Bloomfield, C. D., Andreeff, M., Croce, C. M. (2008). MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 111: 3183-3189 [Abstract] [Full Text]  
• Garzon, R., Garofalo, M., Martelli, M. P., Briesewitz, R., Wang, L., Fernandez-Cymering, C., Volinia, S., Liu, C.-G., Schnittger, S., Haferlach, T., Liso, A., Diverio, D., Mancini, M., Meloni, G., Foa, R., Martelli, M. F., Mecucci, C., Croce, C. M., Falini, B. (2008). Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc. Natl. Acad. Sci. USA 105: 3945-3950 [Abstract] [Full Text]  
• Bemis, L. T., Chen, R., Amato, C. M., Classen, E. H., Robinson, S. E., Coffey, D. G., Erickson, P. F., Shellman, Y. G., Robinson, W. A. (2008). MicroRNA-137 Targets Microphthalmia-Associated Transcription Factor in Melanoma Cell Lines. Cancer Res. 68: 1362-1368 [Abstract] [Full Text]  
• Chim, S. S.C., Shing, T. K.F., Hung, E. C.W., Leung, T.-y., Lau, T.-k., Chiu, R. W.K., Dennis Lo, Y.M. (2008). Detection and Characterization of Placental MicroRNAs in Maternal Plasma. Clin. Chem. 54: 482-490 [Abstract] [Full Text]  
• Feber, A., Xi, L., Luketich, J. D., Pennathur, A., Landreneau, R. J., Wu, M., Swanson, S. J., Godfrey, T. E., Litle, V. R. (2008). MicroRNA expression profiles of esophageal cancer.. J. Thorac. Cardiovasc. Surg. 135: 255-260 [Abstract] [Full Text]  
• Huppi, K., Volfovsky, N., Runfola, T., Jones, T. L., Mackiewicz, M., Martin, S. E., Mushinski, J. F., Stephens, R., Caplen, N. J. (2008). The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24. Mol Cancer Res 6: 212-221 [Abstract] [Full Text]  
• Croce, C. M. (2008). Oncogenes and Cancer. NEJM 358: 502-511 [Full Text]  
• Schetter, A. J., Leung, S. Y., Sohn, J. J., Zanetti, K. A., Bowman, E. D., Yanaihara, N., Yuen, S. T., Chan, T. L., Kwong, D. L. W., Au, G. K. H., Liu, C.-G., Calin, G. A., Croce, C. M., Harris, C. C. (2008). MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma. JAMA 299: 425-436 [Abstract] [Full Text]  
• Guo, Y., Chen, Z., Zhang, L., Zhou, F., Shi, S., Feng, X., Li, B., Meng, X., Ma, X., Luo, M., Shao, K., Li, N., Qiu, B., Mitchelson, K., Cheng, J., He, J. (2008). Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma. Cancer Res. 68: 26-33 [Abstract] [Full Text]  
• Lee, E. J., Baek, M., Gusev, Y., Brackett, D. J., Nuovo, G. J., Schmittgen, T. D. (2008). Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA 14: 35-42 [Abstract] [Full Text]  
• Kipps, T. J. (2008). Chronic Lymphocytic Leukemia: Prognostic Markers and Revised Criteria for Treatment and Response Assessment. Am Soc Clin Oncol Ed Book 2008: 286-290 [Abstract] [Full Text]  
• Sempere, L. F., Christensen, M., Silahtaroglu, A., Bak, M., Heath, C. V., Schwartz, G., Wells, W., Kauppinen, S., Cole, C. N. (2007). Altered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer. Cancer Res. 67: 11612-11620 [Abstract] [Full Text]  
• Latronico, M. V.G., Catalucci, D., Condorelli, G. (2007). Emerging Role of MicroRNAs in Cardiovascular Biology. Circ. Res. 101: 1225-1236 [Abstract] [Full Text]  
• Dai, Y., Huang, Y.-S., Tang, M., Lv, T.-Y., Hu, C.-X., Tan, Y.-H., Xu, Z.-M., Yin, Y.-B. (2007). Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus 16: 939-946 [Abstract]  
• Saini, H. K., Griffiths-Jones, S., Enright, A. J. (2007). Genomic analysis of human microRNA transcripts. Proc. Natl. Acad. Sci. USA 104: 17719-17724 [Abstract] [Full Text]  
• Lu, L., Katsaros, D., Rigault de la Longrais, I. A., Sochirca, O., Yu, H. (2007). Hypermethylation of let-7a-3 in Epithelial Ovarian Cancer Is Associated with Low Insulin-like Growth Factor-II Expression and Favorable Prognosis. Cancer Res. 67: 10117-10122 [Abstract] [Full Text]  
• Tsimberidou, A. M., Wen, S., O'Brien, S., McLaughlin, P., Wierda, W. G., Ferrajoli, A., Faderl, S., Manning, J., Lerner, S., Mai, C. V., Rodriguez, A. M., Hess, M., Do, K.-A., Freireich, E. J., Kantarjian, H. M., Medeiros, L. J., Keating, M. J. (2007). Assessment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma by Absolute Lymphocyte Counts in 2,126 Patients: 20 Years of Experience at The University of Texas M.D. Anderson Cancer Center. JCO 25: 4648-4656 [Abstract] [Full Text]  
• Gironella, M., Seux, M., Xie, M.-J., Cano, C., Tomasini, R., Gommeaux, J., Garcia, S., Nowak, J., Yeung, M. L., Jeang, K.-T., Chaix, A., Fazli, L., Motoo, Y., Wang, Q., Rocchi, P., Russo, A., Gleave, M., Dagorn, J.-C., Iovanna, J. L., Carrier, A., Pebusque, M.-J., Dusetti, N. J. (2007). Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc. Natl. Acad. Sci. USA 104: 16170-16175 [Abstract] [Full Text]  
• Tsuchiya, N., Ochiai, M., Nakashima, K., Ubagai, T., Sugimura, T., Nakagama, H. (2007). SND1, a Component of RNA-Induced Silencing Complex, Is Up-regulated in Human Colon Cancers and Implicated in Early Stage Colon Carcinogenesis. Cancer Res. 67: 9568-9576 [Abstract] [Full Text]  
• Tang, X., Gal, J., Zhuang, X., Wang, W., Zhu, H., Tang, G. (2007). A simple array platform for microRNA analysis and its application in mouse tissues. RNA 13: 1803-1822 [Abstract] [Full Text]  
• Xi, Y., Nakajima, G., Gavin, E., Morris, C. G., Kudo, K., Hayashi, K., Ju, J. (2007). Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA 13: 1668-1674 [Abstract] [Full Text]  
• Tazawa, H., Tsuchiya, N., Izumiya, M., Nakagama, H. (2007). Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc. Natl. Acad. Sci. USA 104: 15472-15477 [Abstract] [Full Text]  
• Iorio, M. V., Visone, R., Di Leva, G., Donati, V., Petrocca, F., Casalini, P., Taccioli, C., Volinia, S., Liu, C.-G., Alder, H., Calin, G. A., Menard, S., Croce, C. M. (2007). MicroRNA Signatures in Human Ovarian Cancer. Cancer Res. 67: 8699-8707 [Abstract] [Full Text]  
• Corney, D. C., Flesken-Nikitin, A., Godwin, A. K., Wang, W., Nikitin, A. Yu. (2007). MicroRNA-34b and MicroRNA-34c Are Targets of p53 and Cooperate in Control of Cell Proliferation and Adhesion-Independent Growth. Cancer Res. 67: 8433-8438 [Abstract] [Full Text]  
• Berkhout, B., Jeang, K.-T. (2007). RISCy Business: MicroRNAs, Pathogenesis, and Viruses. J. Biol. Chem. 282: 26641-26645 [Full Text]  
• Zhang, W., Dahlberg, J. E., Tam, W. (2007). MicroRNAs in Tumorigenesis: A Primer. Am. J. Pathol. 171: 728-738 [Abstract] [Full Text]  
• Galardi, S., Mercatelli, N., Giorda, E., Massalini, S., Frajese, G. V., Ciafre, S. A., Farace, M. G. (2007). miR-221 and miR-222 Expression Affects the Proliferation Potential of Human Prostate Carcinoma Cell Lines by Targeting p27Kip1. J. Biol. Chem. 282: 23716-23724 [Abstract] [Full Text]  
• Goga, A., Benz, C. (2007). Anti-Oncomir Suppression of Tumor Phenotypes. Mol. Interv. 7: 199-202 [Abstract] [Full Text]  
• Yu, Z., Li, Z., Jolicoeur, N., Zhang, L., Fortin, Y., Wang, E., Wu, M., Shen, S.-H. (2007). Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. Nucleic Acids Res 35: 4535-4541 [Abstract] [Full Text]  
• Lui, W.-O., Pourmand, N., Patterson, B. K., Fire, A. (2007). Patterns of Known and Novel Small RNAs in Human Cervical Cancer. Cancer Res. 67: 6031-6043 [Abstract] [Full Text]  
• Gramantieri, L., Ferracin, M., Fornari, F., Veronese, A., Sabbioni, S., Liu, C.-G., Calin, G. A., Giovannini, C., Ferrazzi, E., Grazi, G. L., Croce, C. M., Bolondi, L., Negrini, M. (2007). Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma. Cancer Res. 67: 6092-6099 [Abstract] [Full Text]  
• Porkka, K. P., Pfeiffer, M. J., Waltering, K. K., Vessella, R. L., Tammela, T. L.J., Visakorpi, T. (2007). MicroRNA Expression Profiling in Prostate Cancer. Cancer Res. 67: 6130-6135 [Abstract] [Full Text]  
• Kipps, T. J. (2007). MicroRNAs play a role in neoplasia. Blood 109: 5071-5072 [Full Text]  
• Raveche, E. S., Salerno, E., Scaglione, B. J., Manohar, V., Abbasi, F., Lin, Y.-C., Fredrickson, T., Landgraf, P., Ramachandra, S., Huppi, K., Toro, J. R., Zenger, V. E., Metcalf, R. A., Marti, G. E. (2007). Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 109: 5079-5086 [Abstract] [Full Text]  
• Pasternak, A., Kierzek, E., Pasternak, K., Turner, D. H., Kierzek, R. (2007). A chemical synthesis of LNA-2,6-diaminopurine riboside, and the influence of 2'-O-methyl-2,6-diaminopurine and LNA-2,6-diaminopurine ribosides on the thermodynamic properties of 2'-O-methyl RNA/RNA heteroduplexes. Nucleic Acids Res 0: gkm421v1-9 [Abstract] [Full Text]  
• Negrini, M., Ferracin, M., Sabbioni, S., Croce, C. M. (2007). MicroRNAs in human cancer: from research to therapy. J. Cell Sci. 120: 1833-1840 [Abstract] [Full Text]  
• Fulci, V., Chiaretti, S., Goldoni, M., Azzalin, G., Carucci, N., Tavolaro, S., Castellano, L., Magrelli, A., Citarella, F., Messina, M., Maggio, R., Peragine, N., Santangelo, S., Mauro, F. R., Landgraf, P., Tuschl, T., Weir, D. B., Chien, M., Russo, J. J., Ju, J., Sheridan, R., Sander, C., Zavolan, M., Guarini, A., Foa, R., Macino, G. (2007). Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood 109: 4944-4951 [Abstract] [Full Text]  
• Sevignani, C., Calin, G. A., Nnadi, S. C., Shimizu, M., Davuluri, R. V., Hyslop, T., Demant, P., Croce, C. M., Siracusa, L. D. (2007). MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc. Natl. Acad. Sci. USA 104: 8017-8022 [Abstract] [Full Text]  
• Bloomston, M., Frankel, W. L., Petrocca, F., Volinia, S., Alder, H., Hagan, J. P., Liu, C.-G., Bhatt, D., Taccioli, C., Croce, C. M. (2007). MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis. JAMA 297: 1901-1908 [Abstract] [Full Text]  
• Blenkiron, C., Miska, E. A. (2007). miRNAs in cancer: approaches, aetiology, diagnostics and therapy. Hum Mol Genet 16: R106-R113 [Abstract] [Full Text]  
• Linsley, P. S., Schelter, J., Burchard, J., Kibukawa, M., Martin, M. M., Bartz, S. R., Johnson, J. M., Cummins, J. M., Raymond, C. K., Dai, H., Chau, N., Cleary, M., Jackson, A. L., Carleton, M., Lim, L. (2007). Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression. Mol. Cell. Biol. 27: 2240-2252 [Abstract] [Full Text]  
• Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., Davuluri, R., Liu, C.-G., Croce, C. M., Negrini, M., Calin, G. A., Ivan, M. (2007). A MicroRNA Signature of Hypoxia. Mol. Cell. Biol. 27: 1859-1867 [Abstract] [Full Text]  
• Brueckner, B., Stresemann, C., Kuner, R., Mund, C., Musch, T., Meister, M., Sultmann, H., Lyko, F. (2007). The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function. Cancer Res. 67: 1419-1423 [Abstract] [Full Text]  
• Agnelli, L., Bicciato, S., Fabris, S., Baldini, L., Morabito, F., Intini, D., Verdelli, D., Callegaro, A., Bertoni, F., Lambertenghi-Deliliers, G., Lombardi, L., Neri, A. (2007). Integrative genomic analysis reveals distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma. haematol 92: 56-65 [Abstract] [Full Text]  
• Mattes, J., Yang, M., Foster, P. S. (2007). Regulation of MicroRNA by Antagomirs: A New Class of Pharmacological Antagonists for the Specific Regulation of Gene Function?. Am. J. Respir. Cell Mol. Bio. 36: 8-12 [Abstract] [Full Text]  
• Osada, H., Takahashi, T. (2007). MicroRNAs in biological processes and carcinogenesis. Carcinogenesis 28: 2-12 [Abstract] [Full Text]  
• Mims, M. P., Prchal, J. T. (2007). Molecular basis of hematology. ASH-SAP 2007: 1-22 [Full Text]  
• Goldin, L. R., Slager, S. L. (2007). Familial CLL: Genes and Environment. ASH Education Book 2007: 339-345 [Abstract] [Full Text]  
• Pekarsky, Y., Santanam, U., Cimmino, A., Palamarchuk, A., Efanov, A., Maximov, V., Volinia, S., Alder, H., Liu, C.-G., Rassenti, L., Calin, G. A., Hagan, J. P., Kipps, T., Croce, C. M. (2006). Tcl1 Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181. Cancer Res. 66: 11590-11593 [Abstract] [Full Text]  
• Shivdasani, R. A. (2006). MicroRNAs: regulators of gene expression and cell differentiation. Blood 108: 3646-3653 [Abstract] [Full Text]  
• Marsit, C. J., Eddy, K., Kelsey, K. T. (2006). MicroRNA Responses to Cellular Stress.. Cancer Res. 66: 10843-10848 [Abstract] [Full Text]  
• Takada, S., Berezikov, E., Yamashita, Y., Lagos-Quintana, M., Kloosterman, W. P., Enomoto, M., Hatanaka, H., Fujiwara, S.-i., Watanabe, H., Soda, M., Choi, Y. L., Plasterk, R. H. A., Cuppen, E., Mano, H. (2006). Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res 34: e115-e115 [Abstract] [Full Text]  
• Roldo, C., Missiaglia, E., Hagan, J. P., Falconi, M., Capelli, P., Bersani, S., Calin, G. A., Volinia, S., Liu, C.-G., Scarpa, A., Croce, C. M. (2006). MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior. JCO 24: 4677-4684 [Abstract] [Full Text]  
• Berezikov, E., van Tetering, G., Verheul, M., van de Belt, J., van Laake, L., Vos, J., Verloop, R., van de Wetering, M., Guryev, V., Takada, S., van Zonneveld, A. J., Mano, H., Plasterk, R., Cuppen, E. (2006). Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res. 16: 1289-1298 [Abstract] [Full Text]  
• Weber, F., Teresi, R. E., Broelsch, C. E., Frilling, A., Eng, C. (2006). A Limited Set of Human MicroRNA Is Deregulated in Follicular Thyroid Carcinoma. J. Clin. Endocrinol. Metab. 91: 3584-3591 [Abstract] [Full Text]  
• Taganov, K. D., Boldin, M. P., Chang, K.-J., Baltimore, D. (2006). NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 103: 12481-12486 [Abstract] [Full Text]  
• Diederichs, S., Haber, D. A. (2006). Sequence Variations of MicroRNAs in Human Cancer: Alterations in Predicted Secondary Structure Do Not Affect Processing.. Cancer Res. 66: 6097-6104 [Abstract] [Full Text]  
• Zhang, L., Huang, J., Yang, N., Greshock, J., Megraw, M. S., Giannakakis, A., Liang, S., Naylor, T. L., Barchetti, A., Ward, M. R., Yao, G., Medina, A., O'Brien-Jenkins, A., Katsaros, D., Hatzigeorgiou, A., Gimotty, P. A., Weber, B. L., Coukos, G. (2006). microRNAs exhibit high frequency genomic alterations in human cancer. Proc. Natl. Acad. Sci. USA 103: 9136-9141 [Abstract] [Full Text]  
• Pallante, P, Visone, R, Ferracin, M, Ferraro, A, Berlingieri, M T, Troncone, G, Chiappetta, G, Liu, C G, Santoro, M, Negrini, M, Croce, C M, Fusco, A (2006). MicroRNA deregulation in human thyroid papillary carcinomas.. Endocr Relat Cancer 13: 497-508 [Abstract] [Full Text]  
• Mattick, J. S., Makunin, I. V. (2006). Non-coding RNA.. Hum Mol Genet 15: R17-R29 [Abstract] [Full Text]  
• Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., Prueitt, R. L., Yanaihara, N., Lanza, G., Scarpa, A., Vecchione, A., Negrini, M., Harris, C. C., Croce, C. M. (2006). A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. USA 103: 2257-2261 [Abstract] [Full Text]  
• Borkhardt, A., Fuchs, U., Tuschl, T., Chng, W. J., Calin, G. A., Cimmino, A., Croce, C. M. (2006). MicroRNA in chronic lymphocytic leukemia.. NEJM 354: 524-525 [Full Text]  
• Montserrat, E. (2006). New Prognostic Markers in CLL. ASH Education Book 2006: 279-284 [Abstract] [Full Text]