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Previous Volume 353:2042-2055 November 10, 2005 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Joseph Priestley, one of the three scientists credited with the discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, "For as a candle burns much faster in dephlogisticated [oxygen-enriched] than in common air, so we might live out too fast, and the animal powers be too soon exhausted in this pure kind of air. A moralist, at least, may say, that the air which nature has provided for us is as good as we deserve."¹

In this review we examine the remarkable . . . [Full Text of this Article]

Hypoxic Pulmonary Vasoconstriction

The Smooth-Muscle-Cell Membrane

Release of Calcium from the Sarcoplasmic Reticulum

RhoA/Rho-Kinase Augmentation of Hypoxic Pulmonary Vasoconstriction

Normoxic Constriction of the Ductus Arteriosus

Hypoxic Stimulation of the Carotid Body

Other Examples of Oxygen Sensing by Potassium Channels

The Placenta

Neuroepithelial Bodies

Adrenal Chromaffin Cells

Other Tissues

Oxygen Signaling

Effects of Changes in the Reduction–Oxidation (Redox) Reaction

Sources of Reactive Oxygen Species

Mitochondria and Oxygen Sensing in the Carotid Body

Redox Changes and Channel Gating

Clinical Significance

Pulmonary Hypertension

High-Altitude Pulmonary Edema

Ductus Arteriosus

Oxygen Sensing in the Carotid Body

Conclusions

Source Information

From the Department of Medicine, Minneapolis Veterans Affairs Medical Center and University of Minnesota, Minneapolis (E.K.W.); the Laboratorio de Investigaciones Biomédicas, Hospital Virgen del Rocío, Universidad de Sevilla, Seville, Spain (J.L.-B.); the Department of Physiology, Oxford University, Oxford, England (K.J.B.); and the Department of Medicine and Physiology, University of Alberta, Edmonton, Alta., Canada (S.L.A.).

Address reprint requests to Dr. Weir at the VA Medical Center 111C, 1 Veterans Dr., Minneapolis, MN 55417, or at weirx002@umn.edu.

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Extract | Full Text | PDF  
N Engl J Med 2006; 354:975-977, Mar 2, 2006. Correspondence

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