FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 353:2074-2077 November 10, 2005 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

One of the key ideas behind sequencing the human genome was the promise of "personalized medicine." The idea was that genetic information could be used to make health care more precise, efficacious, and safe. The Human Genome Project showed us that among humans, DNA sequences are 99.9 percent similar, but the remaining 0.1 percent, in the context of environmental and epigenetic factors, produces the entirety of genetic variability within the human population. How can we use the information about human genetic variation to achieve these stated goals of the genome-sequencing effort?¹ Investigators are currently collecting phenotypic information about patients (their . . . [Full Text of this Article]

The Effects on Clinical Genomic Research of Large Populations That Have Been Phenotyped

Cause for Concern: No Perfect Anonymity

The Risks of Sharing Data

Varying Levels of Concern

A Potential Solution and a Proposal

Source Information

From the Department of Pediatrics, Children's Hospital and Harvard Medical School, Boston (I.S.K.); and the Department of Genetics, Stanford University, Stanford, Calif. (R.B.A.).

Related Letters:

Health-Information Altruists
Winickoff D. E., Kohane I. S., Altman R. B.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:530-531, Feb 2, 2006. Correspondence

This article has been cited by other articles:

• Mandl, K. D., Kohane, I. S. (2008). Tectonic Shifts in the Health Information Economy. NEJM 358: 1732-1737 [Full Text]  
• Halamka, J. D., Mandl, K. D., Tang, P. C. (2008). Early Experiences with Personal Health Records. J. Am. Med. Inform. Assoc. 15: 1-7 [Abstract] [Full Text]  
• McMurry, A. J., Gilbert, C. A., Reis, B. Y., Chueh, H. C., Kohane, I. S., Mandl, K. D. (2007). A Self-scaling, Distributed Information Architecture for Public Health, Research, and Clinical Care. J. Am. Med. Inform. Assoc. 14: 527-533 [Abstract] [Full Text]  
• Kohane, I. S., Masys, D. R., Altman, R. B. (2006). The incidentalome: a threat to genomic medicine.. JAMA 296: 212-215 [Full Text]  
• Winickoff, D. E., Kohane, I. S., Altman, R. B. (2006). Health-Information Altruists. NEJM 354: 530-531 [Full Text]