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Previous Volume 353:209-210 July 14, 2005 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Lynch et al.¹ and Paez et al.² correlated the presence of somatic mutations in the tyrosine kinase domain of the gene that encodes the epidermal growth factor receptor (EGFR) with responsiveness to gefitinib in non–small-cell lung carcinoma. Neuroendocrine differentiation is present in a substantial number of gastroenteropancreatic neuroendocrine tumors,³ and EGFR expression occurs in such tumors.⁴

We sought EGFR-activating mutations in a series of rare gastroenteropancreatic neuroendocrine cancers. DNA was isolated from flash-frozen specimens of carcinoid and pancreatic endocrine tumors; EGFR exons 18, 19, and 21 were amplified by the polymerase chain reaction with primers . . . [Full Text of this Article]

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