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Previous Volume 353:2104-2107 November 17, 2005 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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As with other cancers, the process of the transformation of normal melanocytes into malignant melanoma requires the acquisition of genomic abnormalities. Although progress in the search for the targets of genetic aberration in cancer has been stunning in many respects, the clinical effect of this work has been limited. But it is clear that tracking down the genetic changes in cancer is no mere academic exercise; rather, it has proved to be a powerful approach to the selection of therapeutic targets. Progress in the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumor, and some lung cancers can be directly linked . . . [Full Text of this Article]

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Dr. Meltzer is head of the Section of Molecular Genetics, Cancer Genetics Branch, of the National Human Genome Research Institute, Bethesda, Md.

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