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Previous Volume 353:2192-2194 November 17, 2005 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The causal links between bariatric surgery and pancreatic nesidioblastosis are unclear. Service et al. (July 21 issue)¹ suggest a link between nesidioblastosis and glucagon-like peptide 1 (GLP-1), since GLP-1 causes beta-cell expansion in animal models of diabetes. GLP-1 and the incretin mimetic exenatide enhance insulin secretion in a glucose-dependent manner.^2,3 Similarly, incretin-induced beta-cell expansion appears to be glucose-dependent. It is relevant that studies of two years' duration in normal mice and rats of exenatide at doses of more than 100 times those given to humans showed no pathological changes in the islets (data on file, Amylin Pharmaceuticals); . . . [Full Text of this Article]

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