Edited by Sudhesh Kumar and Stephen O'Rahilly. 599 pp., illustrated. Chichester, England, John Wiley & Sons, 2005. $190. ISBN 0-470-85008-6.
Although insulin resistance was originally viewed as a totalinability of insulin to stimulate the metabolism of carbohydrates,the work of Harold Himsworth in the 1930s made it clear thatinsulin's stimulatory effect varies widely among people, includingthose without diabetes. Since the 1960s, insulin resistance,along with beta-cell defects, has been implicated in the pathogenesisof type 2 diabetes mellitus. More recently, Gerald Reaven andothers have popularized the concept that insulin resistancein itself is a risk factor for many chronic ailments, includinghypertension, cardiovascular disease, and some cancers. Insulinresistance is a hallmark of the so-called metabolic . . . [Full Text of this Article]
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