The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Clinical Implications of Basic Research
PreviousPrevious
Volume 353:2297-2299 November 24, 2005 Number 21
NextNext

Inducing Intestinal Growth
Clara Abraham, M.D., and Judy H. Cho, M.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-PubMed Citation
The small-intestinal epithelium is composed of proliferative-crypt and differentiating-villus compartments. Pluripotent stem cells (believed to reside near crypt bases) give rise to progenitors that proliferate and migrate either toward the villus while differentiating into enterocyte, goblet, and enteroendocrine cells or toward the crypt bases while differentiating into Paneth cells. The signaling pathway mediated by the Wnt–{beta}-catenin cascade has a central role in determining the balance of these different types of cells — in other words, it has an important influence on the cell's tendency to differentiate or proliferate. The discovery by Kim and colleagues1 that R-spondin1, a newly identified . . . [Full Text of this Article]


Source Information

From the Department of Medicine, University of Chicago, Chicago.



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.