This Journal feature begins with a case vignette highlightinga common clinical problem. Evidence supporting various strategiesis then presented, followed by a review of formal guidelines,when they exist. The article ends with the authors' clinicalrecommendations.
A 38-year-old man notes abrupt loss of vision in his right visualfield while reading. He has no significant medical history andreports that he neither smokes nor uses alcohol or illicit drugs.Physical examination reveals right homonymous hemianopia butno other abnormalities. Magnetic resonance imaging reveals acuteleft occipital infarction and normal head and neck vessels.Transesophageal echocardiography shows a patent . . . [Full Text of this Article]
The Clinical Problem
Patent Foramen Ovale and the Risk of Stroke
Atrial Septal Aneurysm
Strategies and Evidence
Evaluation
Treatment
Medical Therapy
Mechanical Closure
Areas of Uncertainty
Guidelines
Conclusions and Recommendations
Source Information
From the Departments of Medicine (J.R.K., R.B.D.) and Public Health (J.R.K.), Weill Medical College of Cornell University, New York.
Address reprint requests to Dr. Kizer at Box 222, New YorkPresbyterian Hospital, 525 E. 68th St., New York, NY 10021, or at jok2007@med.cornell.edu.
Doufekias, E., Segal, A. Z., Kizer, J. R.
(2008). Cardiogenic and aortogenic brain embolism.. J Am Coll Cardiol
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Weir, N U
(2008). An update on cardioembolic stroke. Postgrad. Med. J.
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Mareedu, R. K., Shah, M. S., Mesa, J. E., McCauley, C. S.
(2007). Percutaneous Closure of Patent Foramen Ovale: A Case Series and Literature Review. Clin Med Res
5: 218-226
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Gurtu, R., Grocott-Mason, R., Mason, M., Ilsley, C., Dubrey, S. W.
(2007). Paradoxical coronary emboli following a long-haul airline flight. Eur J Echocardiogr
8: 390-392
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Sukernik, M. R., Bennett-Guerrero, E.
(2007). The Incidental Finding of a Patent Foramen Ovale During Cardiac Surgery: Should It Always Be Repaired? A Core Review. Anesth. Analg.
105: 602-610
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Slottow, T. L. P., Steinberg, D. H., Waksman, R.
(2007). Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel Meeting on Patent Foramen Ovale Closure Devices. Circulation
116: 677-682
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Di Tullio, M. R., Sacco, R. L., Sciacca, R. R., Jin, Z., Homma, S.
(2007). Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population. J Am Coll Cardiol
49: 797-802
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McCabe, D J H, Rakhit, R D
(2007). Antithrombotic and interventional treatment options in cardioembolic transient ischaemic attack and ischaemic stroke. J. Neurol. Neurosurg. Psychiatry
78: 14-24
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Malani, A. K., Ammar, H.
(2006). Cryptogenic stroke and patent foramen ovale.. ANN INTERN MED
145: 393-394
[Full Text]
Bonati, L. H., Kessel-Schaefer, A., Linka, A. Z., Buser, P., Wetzel, S. G., Radue, E.-W., Lyrer, P. A., Engelter, S. T.
(2006). Diffusion-Weighted Imaging in Stroke Attributable to Patent Foramen Ovale: Significance of Concomitant Atrial Septum Aneurysm. Stroke
37: 2030-2034
[Abstract][Full Text]
Albin, M. S., Wills, J., Schwend, R. M., Mazzucco, S., Anzola, G. P., Kizer, J. R., Devereux, R. B.
(2006). Patent foramen ovale and unexplained stroke.. NEJM
354: 1753-1755
[Full Text]
(2006). Perspective on PFO in Cryptogenic Stroke. JWatch Neurology
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Hegland, D. D., Kunz, G. A., Harrison, J. K., Wang, A.
(2005). Clinical problem-solving. A hole in the argument.. NEJM
353: 2385-2390
[Full Text]