During the past 20 years, there have been many reports of thepresence of inflammatory and immune-cell infiltrates in variousneoplasms, including colorectal cancer. Initially, these findingswere thought to indicate that although the immune system canrecognize autologous tumor cells, it mounts an ineffective responseto them. In the 1990s, functional studies demonstrated the presenceof HLA-restricted T cells specific for colorectal cancer inpopulations of tumor-infiltrating lymphocytes and peripheral-bloodmononuclear cells from patients with colorectal cancer. Sincethere were negligible numbers of such T cells in the blood ofcontrol subjects, the findings indicated that some of the . . . [Full Text of this Article]
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Dr. Parmiani is the chairman of the Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan.
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