FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 353:2758-2768 December 29, 2005 Number 26 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background The appropriate treatment for patients in whom reperfusion fails to occur after thrombolytic therapy for acute myocardial infarction remains unclear. There are few data comparing emergency percutaneous coronary intervention (rescue PCI) with conservative care in such patients, and none comparing rescue PCI with repeated thrombolysis.

Methods We conducted a multicenter trial in the United Kingdom involving 427 patients with ST-segment elevation myocardial infarction in whom reperfusion failed to occur (less than 50 percent ST-segment resolution) within 90 minutes after thrombolytic treatment. The patients were randomly assigned to repeated thrombolysis (142 patients), conservative treatment (141 patients), or rescue PCI (144 patients). The primary end point was a composite of death, reinfarction, stroke, or severe heart failure within six months.

Results The rate of event-free survival among patients treated with rescue PCI was 84.6 percent, as compared with 70.1 percent among those receiving conservative therapy and 68.7 percent among those undergoing repeated thrombolysis (overall P=0.004). The adjusted hazard ratio for the occurrence of the primary end point for repeated thrombolysis versus conservative therapy was 1.09 (95 percent confidence interval, 0.71 to 1.67; P=0.69), as compared with adjusted hazard ratios of 0.43 (95 percent confidence interval, 0.26 to 0.72; P=0.001) for rescue PCI versus repeated thrombolysis and 0.47 (95 percent confidence interval, 0.28 to 0.79; P=0.004) for rescue PCI versus conservative therapy. There were no significant differences in mortality from all causes. Nonfatal bleeding, mostly at the sheath-insertion site, was more common with rescue PCI. At six months, 86.2 percent of the rescue-PCI group were free from revascularization, as compared with 77.6 percent of the conservative-therapy group and 74.4 percent of the repeated-thrombolysis group (overall P=0.05).

Conclusions Event-free survival after failed thrombolytic therapy was significantly higher with rescue PCI than with repeated thrombolysis or conservative treatment. Rescue PCI should be considered for patients in whom reperfusion fails to occur after thrombolytic therapy.

Source Information

From the Department of Cardiology, University Hospitals of Leicester, Leicester (A.H.G., A.S.-L., S.H.); the Departments of Health Sciences (K.R.A.) and Cardiovascular Sciences (S.E.S.), University of Leicester, Leicester; the Department of Cardiology, Royal Infirmary Edinburgh, Edinburgh (N.G.U.); Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton (A. de Belder); the Department of Cardiology, North Staffordshire Hospital, Stoke-on-Trent (J.D.); the Department of Cardiology, Heartlands Hospital, Birmingham (M.P.); the Department of Cardiology, John Radcliffe Hospital, Oxford (A. Banning); the Department of Cardiology, Bristol Royal Infirmary, Bristol (A. Baumbach); the Department of Cardiology, Walsgrave Hospital, Coventry (M.F.S.); the Department of Cardiology, Papworth Hospital, Cambridge (P.S.); Wessex Cardiac Unit, Southampton General Hospital, Southampton (K.D.D.); Trent Cardiac Centre, Nottingham City Hospital, Nottingham (R.A.H.); the Department of Cardiology, Western Infirmary, Glasgow (K.G.O.); and the Department of Cardiovascular Medicine, Queens Medical Centre, Nottingham (R.W.) — all in the United Kingdom.

Address reprint requests to Dr. Gershlick at the University Hospitals of Leicester, Groby St., Leicester LE3 9QP, United Kingdom, or at agershlick{at}aol.com.

Full Text of this Article

Related Letters:

Rescue Angioplasty after Thrombolysis
Owen A., Aziz S., Ramsdale D., Sharma S., Bhambi B., Nyitray W., Viswanathan G. N., Sankar S., Gershlick A. H., Stephens-Lloyd A., Wilcox R.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:1639-1641, Apr 13, 2006. Correspondence

This article has been cited by other articles:

• Kushner, F. G., Hand, M., Smith, S. C. Jr, King, S. B. III, Anderson, J. L., Antman, E. M., Bailey, S. R., Bates, E. R., Blankenship, J. C., Casey, D. E. Jr, Green, L. A., Hochman, J. S., Jacobs, A. K., Krumholz, H. M., Morrison, D. A., Ornato, J. P., Pearle, D. L., Peterson, E. D., Sloan, M. A., Whitlow, P. L., Williams, D. O. (2009). 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 54: 2205-2241 [Full Text]  
• Kumar, A., Cannon, C. P. (2009). Acute Coronary Syndromes: Diagnosis and Management, Part II. Mayo Clin Proc. 84: 1021-1036 [Abstract] [Full Text]  
• Danchin, N. (2009). Systems of Care for ST-Segment Elevation Myocardial Infarction: Impact of Different Models on Clinical Outcomes. J Am Coll Cardiol Intv 2: 901-908 [Abstract] [Full Text]  
• Ross, A. M., Huber, K., Zeymer, U., Armstrong, P. W., Granger, C. B., Goldstein, P., Bogaerts, K., Van de Werf, F. (2009). The Impact of Place of Enrollment and Delay to Reperfusion on 90-Day Post-Infarction Mortality in the ASSENT-4 PCI Trial: Assessment of the Safety and Efficacy of a New Treatment Strategy With Percutaneous Coronary Intervention. J Am Coll Cardiol Intv 2: 925-930 [Abstract] [Full Text]  
• Bartholomew, L. K., Cushman, W. C, Cutler, J. A, Davis, B. R, Dawson, G., Einhorn, P. T, Graumlich, J. F, Piller, L. B, Pressel, S., Roccella, E. J, Simpson, L., Whelton, P. K, Williard, A., ALLHAT Collaborative Research Group, (2009). Getting clinical trial results into practice: design, implementation, and process evaluation of the ALLHAT Dissemination Project. Clin Trials 6: 329-343 [Abstract]  
• Carver, A., Rafelt, S., Gershlick, A. H., Fairbrother, K. L., Hughes, S., Wilcox, R., for the REACT Investigators, (2009). Longer-Term Follow-Up of Patients Recruited to the REACT (Rescue Angioplasty Versus Conservative Treatment or Repeat Thrombolysis) Trial.. J Am Coll Cardiol 54: 118-126 [Abstract] [Full Text]  
• Ndrepepa, G., Schomig, A., Kastrati, A. (2009). The Only Better Alternative to Rescue Percutaneous Coronary Intervention Is Primary Percutaneous Coronary Intervention.. J Am Coll Cardiol 54: 127-129 [Full Text]  
• Verheugt, F. W.A. (2009). Routine Angioplasty after Fibrinolysis -- How Early Should "Early" Be?. NEJM 360: 2779-2781 [Full Text]  
• Edmond, J J, Juergens, C P, French, J K (2009). The pharmaco-invasive approach to STEMI: when should fibrinolytic-treated patients go to the "cath lab"?. Postgrad. Med. J. 85: 331-334 [Abstract] [Full Text]  
• Danchin, N., Carda, R., Chaib, A., Lepillier, A., Durand, E. (2009). Optimizing outcomes in patients with STEMI: mortality, bleeding, door-to-balloon times, and guidelines: the approach to regional systems for STEMI care: defining the ideal approach to reperfusion therapy based on recent trials. Eur Heart J Suppl 11: C25-C30 [Abstract] [Full Text]  
• Armstrong, P. W., Westerhout, C. M., Welsh, R. C. (2009). Duration of Symptoms Is the Key Modulator of the Choice of Reperfusion for ST-Elevation Myocardial Infarction. Circulation 119: 1293-1303 [Full Text]  
• Edmond, J J, Juergens, C P, French, J K (2009). The pharmaco-invasive approach to STEMI: when should fibrinolytic-treated patients go to the "cath lab"?. Heart 95: 358-361 [Abstract] [Full Text]  
• Hollenberg, S. M. (2009). Acute Coronary Syndromes. ACCP Crit Care Med Brd Rev 20: 129-144 [Full Text]  
• Hamm, C. W., Möllmann, H., Bassand, J.-P., van de Werf, F. (2009). CHAPTER 16 Acute Coronary Syndromes. ESC Textbook of Cardiovascular Medicine 2: med-9780199566990-chapter-med-9780199566990-chapter [Abstract] [Full Text]  
• Authors/Task Force Members, , Van de Werf, F., Bax, J., Betriu, A., Blomstrom-Lundqvist, C., Crea, F., Falk, V., Filippatos, G., Fox, K., Huber, K., Kastrati, A., Rosengren, A., Steg, P. G., Tubaro, M., Verheugt, F., Weidinger, F., Weis, M., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Silber, S., Aguirre, F. V., Al-Attar, N., Alegria, E., Andreotti, F., Benzer, W., Breithardt, O., Danchin, N., Mario, C. D., Dudek, D., Gulba, D., Halvorsen, S., Kaufmann, P., Kornowski, R., Lip, G. Y. H., Rutten, F. (2008). Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology:. Eur Heart J 29: 2909-2945 [Full Text]  
• Dudek, D., Rakowski, T., Dziewierz, A., Kleczynski, P. (2008). PCI after lytic therapy: when and how?. Eur Heart J Suppl 10: J15-J20 [Abstract] [Full Text]  
• Stone, G. W. (2008). Angioplasty Strategies in ST-Segment-Elevation Myocardial Infarction: Part II: Intervention After Fibrinolytic Therapy, Integrated Treatment Recommendations, and Future Directions. Circulation 118: 552-566 [Full Text]  
• Bates, E. R., Nallamothu, B. K. (2008). Commentary: The Role of Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction. Circulation 118: 567-573 [Full Text]  
• White, H. D. (2008). Systems of Care: Need for Hub-and-Spoke Systems for Both Primary and Systematic Percutaneous Coronary Intervention After Fibrinolysis. Circulation 118: 219-222 [Full Text]  
• Danchin, N., Coste, P., Ferrieres, J., Steg, P.-G., Cottin, Y., Blanchard, D., Belle, L., Ritz, B., Kirkorian, G., Angioi, M., Sans, P., Charbonnier, B., Eltchaninoff, H., Gueret, P., Khalife, K., Asseman, P., Puel, J., Goldstein, P., Cambou, J.-P., Simon, T., for the FAST-MI Investigators, (2008). Comparison of Thrombolysis Followed by Broad Use of Percutaneous Coronary Intervention With Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Acute Myocardial Infarction: Data From the French Registry on Acute ST-Elevation Myocardial Infarction (FAST-MI). Circulation 118: 268-276 [Abstract] [Full Text]  
• Goodman, S. G., Menon, V., Cannon, C. P., Steg, G., Ohman, E. M., Harrington, R. A. (2008). Acute ST-Segment Elevation Myocardial Infarction: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 708S-775S [Abstract] [Full Text]  
• Testa, L., van Gaal, W.J., Biondi-Zoccai, G.G.L., Abbate, A., Agostoni, P., Bhindi, R., Banning, A.P. (2008). Repeat thrombolysis or conservative therapy vs. rescue percutaneous coronary intervention for failed thrombolysis: systematic review and meta-analysis. QJM 101: 387-395 [Abstract] [Full Text]  
• Valgimigli, M., Campo, G., Percoco, G., Bolognese, L., Vassanelli, C., Colangelo, S., de Cesare, N., Rodriguez, A. E., Ferrario, M., Moreno, R., Piva, T., Sheiban, I., Pasquetto, G., Prati, F., Nazzaro, M. S., Parrinello, G., Ferrari, R., for the Multicentre Evaluation of Single High-Dose, (2008). Comparison of Angioplasty With Infusion of Tirofiban or Abciximab and With Implantation of Sirolimus-Eluting or Uncoated Stents for Acute Myocardial Infarction: The MULTISTRATEGY Randomized Trial. JAMA 299: 1788-1799 [Abstract] [Full Text]  
• Abbate, A., Biondi-Zoccai, G. G.L., Appleton, D. L., Erne, P., Schoenenberger, A. W., Lipinski, M. J., Agostoni, P., Sheiban, I., Vetrovec, G. W. (2008). Survival and Cardiac Remodeling Benefits in Patients Undergoing Late Percutaneous Coronary Intervention of the Infarct-Related Artery: Evidence From a Meta-Analysis of Randomized Controlled Trials. J Am Coll Cardiol 51: 956-964 [Abstract] [Full Text]  
• Aguirre, F. V., Varghese, J. J., Kelley, M. P., Lam, W., Lucore, C. L., Gill, J. B., Page, L., Turner, L., Davis, C., Mikell, F. L. (2008). Rural Interhospital Transfer of ST-Elevation Myocardial Infarction Patients for Percutaneous Coronary Revascularization: The Stat Heart Program. Circulation 117: 1145-1152 [Abstract] [Full Text]  
• Hayat, S. A., Senior, R. (2008). Myocardial contrast echocardiography in ST elevation myocardial infarction: ready for prime time?. Eur Heart J 29: 299-314 [Abstract] [Full Text]  
• Labarere, J., Belle, L., Danchin, N. (2008). Better Outcome of Myocardial Infarction in Hospitals With PCI Facilities--Is It Because of More PCIs?--Reply. Arch Intern Med 168: 240-241 [Full Text]  
• American College of Cardiology/American Heart Asso, , Developed in Collaboration With the Canadian Cardi, , Endorsed by the American Academy of Family Physici, , 2007 Writing Group to Review New Evidence and Upda, , Antman, E. M., Hand, M., Armstrong, P. W., Bates, E. R., Green, L. A., Halasyamani, L. K., Hochman, J. S., Krumholz, H. M., Lamas, G. A., Mullany, C. J., Pearle, D. L., Sloan, M. A., Smith, S. C. JR (2008). 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction. J Am Coll Cardiol 51: 210-247 [Full Text]  
• American College of Cardiology/American Heart Asso, , 2007 Writing Group to Review New Evidence and Upda, , King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention. J Am Coll Cardiol 51: 172-209 [Full Text]  
• Antman, E. M., Hand, M., Armstrong, P. W., Bates, E. R., Green, L. A., Halasyamani, L. K., Hochman, J. S., Krumholz, H. M., Lamas, G. A., Mullany, C. J., Pearle, D. L., Sloan, M. A., Smith, S. C. Jr, 2004 Writing Committee Members, , Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., Mullany, C. J., Ornato, J. P., Pearle, D. L., Sloan, M. A., Smith, S. C. Jr, Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Buller, C. E., Creager, M. A., Ettinger, S. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2008). 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the Canadian Cardiovascular Society Endorsed by the American Academy of Family Physicians: 2007 Writing Group to Review New Evidence and Update the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction, Writing on Behalf of the 2004 Writing Committee. Circulation 117: 296-329 [Full Text]  
• King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O., 2005 WRITING COMMITTEE MEMBERS, , Smith, S. C. Jr, Feldman, T. E., Hirshfeld, J. W. Jr, Jacobs, A. K., Kern, M. J., King, S. B. III, Morrison, D. A., O'Neill, W. W., Schaff, H. V., Whitlow, P. L., Williams, D. O., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Buller, C. E., Creager, M. A., Ettinger, S. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence and Update the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention, Writing on Behalf of the 2005 Writing Committee. Circulation 117: 261-295 [Full Text]  
• Fraker, T. D. Jr, Fihn, S. D., Writing on behalf of the 2002 Chronic Stable Angin, (2007). 2007 Chronic Angina Focused Update of the ACC/AHA 2002 Guidelines for the Management of Patients With Chronic Stable Angina: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to Develop the Focused Update of the 2002 Guidelines for the Management of Patients With Chronic Stable Angina. J Am Coll Cardiol 50: 2264-2274 [Full Text]  
• Fraker, T. D. Jr, Fihn, S. D., Writing on behalf of the 2002 Chronic Stable Angin, , 2002 WRITING COMMITTEE MEMBERS, , Gibbons, R. J., Abrams, J., Chatterjee, K., Daley, J., Deedwania, P. C., Douglas, J. S., Ferguson, T. B. Jr, Fihn, S. D., Fraker, T. D. Jr, Gardin, J. M., O'Rourke, R. A., Pasternak, R. C., Williams, S. V., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Buller, C. E., Creager, M. A., Ettinger, S. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2007). 2007 Chronic Angina Focused Update of the ACC/AHA 2002 Guidelines for the Management of Patients With Chronic Stable Angina: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to Develop the Focused Update of the 2002 Guidelines for the Management of Patients With Chronic Stable Angina. Circulation 116: 2762-2772 [Full Text]  
• Jones, J B, Docherty, A (2007). Non-invasive treatment of ST elevation myocardial infarction. Postgrad. Med. J. 83: 725-730 [Abstract] [Full Text]  
• Boden, W. E., Eagle, K., Granger, C. B. (2007). Reperfusion Strategies in Acute ST-Segment Elevation Myocardial Infarction: A Comprehensive Review of Contemporary Management Options. J Am Coll Cardiol 50: 917-929 [Abstract] [Full Text]  
• Sanz, M., Smalling, R. W., Brewer, D. L., French, W. J., Smaha, L. A., Ting, H. H., Casey, D. E. (2007). Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: The Physician Perspective. Circulation 116: e39-e42 [Full Text]  
• Edmond, J.J., French, J.K., Aylward, P.E.G., Wong, C.K., Stewart, R.A.H., Williams, B.F., De Pasquale, C.G., O'Connell, R.L., Van den Berg, K., Van de Werf, F.J., Simes, R.J., White, H.D., for the HERO-2 Investigators, (2007). Variations in the use of emergency PCI for the treatment of re-infarction following intravenous fibrinolytic therapy: impact on outcomes in HERO-2. Eur Heart J 28: 1418-1424 [Abstract] [Full Text]  
• Labarere, J., Belle, L., Fourny, M., Genes, N., Lablanche, J.-M., Blanchard, D., Cambou, J.-P., Danchin, N., for the Unite de Soins Intensifs Coronaires 2000 I, (2007). Outcomes of Myocardial Infarction in Hospitals With Percutaneous Coronary Intervention Facilities. Arch Intern Med 167: 913-920 [Abstract] [Full Text]  
• Eeckhout, E. (2007). RESCUE PERCUTANEOUS CORONARY INTERVENTION: DOES THE CONCEPT MAKE SENSE?. Heart 93: 632-638 [Full Text]  
• Dalby, M., Roughton, M., Ilsley, C., de LaCoussaye, J. E., Carli, P. A., Umans, V. A., Peels, H. O., Wharton, T., Hall, J., Roberts, T., deBelder, M., Townend, J. N., Bradley, E. H., Krumholz, H. M., Moscucci, M., Eagle, K. A. (2007). Door-to-Balloon Time in Acute Myocardial Infarction. NEJM 356: 1475-1479 [Full Text]  
• Siminiak, T., Dudek, D. (2007). Fibrinolysis may widen the time window for primary angioplasty. Eur Heart J 28: 915-917 [Full Text]  
• Legutko, J., Siudak, Z., Dudek, D., Rzeszutko, L. (2007). Percutaneous Coronary Intervention vs Thrombolysis for ST-Elevation Myocardial Infarction. JAMA 297: 1314-1314 [Full Text]  
• Armstrong, P. W. (2007). Ruminating on OAT: is the case closed?. Eur Heart J 28: 531-532 [Full Text]  
• Wijeysundera, H. C., Vijayaraghavan, R., Nallamothu, B. K., Foody, J. M., Krumholz, H. M., Phillips, C. O., Kashani, A., You, J. J., Tu, J. V., Ko, D. T. (2007). Rescue Angioplasty or Repeat Fibrinolysis After Failed Fibrinolytic Therapy for ST-Segment Myocardial Infarction: A Meta-Analysis of Randomized Trials. J Am Coll Cardiol 49: 422-430 [Abstract] [Full Text]  
• Kendall, J (2007). The optimum reperfusion pathway for ST elevation acute myocardial infarction: development of a decision framework. Emerg. Med. J. 24: 52-56 [Abstract] [Full Text]  
• (2006). After Failed Fibrinolysis, Rescue PCI Is Best. Journal Watch Cardiology 2006: 7-7 [Full Text]  
• Ting, H. H., Yang, E. H., Rihal, C. S. (2006). Narrative review: reperfusion strategies for ST-segment elevation myocardial infarction.. ANN INTERN MED 145: 610-617 [Abstract] [Full Text]  
• Kereiakes, D. J., Antman, E. M. (2006). Clinical Guidelines and Practice: In Search of the Truth. J Am Coll Cardiol 48: 1129-1135 [Abstract] [Full Text]  
• Wong, C.-K., Gao, W., Stewart, R. A.H., van Pelt, N., French, J. K., Aylward, P. E.G., White, H. D., on behalf of the Hirulog Early Reperfusion Occlusi, (2006). Risk Stratification of Patients With Acute Anterior Myocardial Infarction and Right Bundle-Branch Block: Importance of QRS Duration and Early ST-Segment Resolution After Fibrinolytic Therapy. Circulation 114: 783-789 [Abstract] [Full Text]  
• Schomig, A., Ndrepepa, G., Kastrati, A. (2006). Late myocardial salvage: time to recognize its reality in the reperfusion therapy of acute myocardial infarction. Eur Heart J 27: 1900-1907 [Abstract] [Full Text]  
• Armstrong, P. W., WEST Steering Committee, (2006). A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study. Eur Heart J 27: 1530-1538 [Abstract] [Full Text]  
• (2006). Additional articles abstracted in ACP Journal Club. Evid. Based Med. 11: 94-94 [Full Text]  
• Verheugt, F. W.A. (2006). Reperfusion Therapy Starts in the Ambulance. Circulation 113: 2377-2379 [Full Text]  
• Kaul, P., Chang, W.-C., Lincoff, A. M., Aylward, P., Betriu, A., Bode, C., Califf, R. M., Ohman, E. M., Guetta, V., Steg, P. G., Van de Werf, F., Armstrong, P. W. (2006). Optimizing use of revascularization and clinical outcomes in ST-elevation myocardial infarction: insights from the GUSTO-V trial. Eur Heart J 27: 1198-1206 [Abstract] [Full Text]  
• Dixon, S. R., Grines, C. L., O'Neill, W. W. (2006). The Year in Interventional Cardiology. J Am Coll Cardiol 47: 1689-1706 [Full Text]  
• Owen, A., Aziz, S., Ramsdale, D., Sharma, S., Bhambi, B., Nyitray, W., Viswanathan, G. N., Sankar, S., Gershlick, A. H., Stephens-Lloyd, A., Wilcox, R. (2006). Rescue Angioplasty after Thrombolysis. NEJM 354: 1639-1641 [Full Text]  
• Malik, I. (2006). JournalScan. Heart 92: 430-432 [Full Text]  
• (2006). Rescue Angioplasty in ST-Segment-Elevation MI?. JWatch General 2006: 4-4 [Full Text]  
• Martyn, C. (2006). What's new in the other general journals. BMJ 332: 105-106 [Full Text]  
• (2006). After Failed Fibrinolysis, Rescue PCI Is Best. Journal Watch Cardiology 2006: 1-1 [Full Text]