This Journal feature begins with a case vignette highlightinga common clinical problem. Evidence supporting various strategiesis then presented, followed by a review of formal guidelines,when they exist. The article ends with the authors' clinicalrecommendations.
A 62-year-old man presents with a three-day history of progressivedyspnea, nonproductive cough, and low-grade fever. He had beenhospitalized two years earlier for congestive heart failure.His blood pressure is 95/55 mm Hg, his heart rate 110 beatsper minute, his temperature 37.9°C, and his oxygen saturationwhile breathing ambient air 86 percent. Chest auscultation revealsrales and rhonchi bilaterally. A . . . [Full Text of this Article]
The Clinical Problem
Strategies and Evidence
Evaluation
History and Physical Examination
Laboratory Testing
Chest Radiography
Echocardiography
Pulmonary-Artery Catheterization
Stepwise Approach
Areas of Uncertainty
Guidelines
Conclusions and Recommendations
Source Information
From the Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville (L.B.W.); and the Departments of Medicine and Anesthesia and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco (M.A.M.).
Address reprint requests to Dr. Ware at the Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, 1161 21st Ave. S., T1218 MCN, Nashville, TN 37232-2650.
This article has been cited by other articles:
Gorovoy, M., Han, J., Pan, H., Welch, E., Neamu, R., Jia, Z., Predescu, D., Vogel, S., Minshall, R. D., Ye, R. D., Malik, A. B., Voyno-Yasenetskaya, T.
(2009). LIM Kinase 1 Promotes Endothelial Barrier Disruption and Neutrophil Infiltration in Mouse Lungs. Circ. Res.
105: 549-556
[Abstract][Full Text]
Wester, T. E., Cherry, A. D., Pollock, N. W., Freiberger, J. J., Natoli, M. J., Schinazi, E. A., Doar, P. O., Boso, A. E., Alford, E. L., Walker, A. J., Uguccioni, D. M., Kernagis, D., Moon, R. E.
(2009). Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA. J. Appl. Physiol.
106: 691-700
[Abstract][Full Text]
Sessler, C. N.
(2009). Hypoxemic Respiratory Failure. ACCP Pulmonary Med Brd Rev
25: 401-414
[Full Text]
Lindholm, P., Lundgren, C. E.
(2009). The physiology and pathophysiology of human breath-hold diving. J. Appl. Physiol.
106: 284-292
[Abstract][Full Text]
Lindholm, P., Ekborn, A., Oberg, D., Gennser, M.
(2008). Pulmonary edema and hemoptysis after breath-hold diving at residual volume. J. Appl. Physiol.
104: 912-917
[Abstract][Full Text]
Jian, M.-Y., King, J. A., Al-Mehdi, A.-B., Liedtke, W., Townsley, M. I.
(2008). High Vascular Pressure-Induced Lung Injury Requires P450 Epoxygenase-Dependent Activation of TRPV4. Am. J. Respir. Cell Mol. Bio.
38: 386-392
[Abstract][Full Text]
Liu, K. D., Matthay, M. A.
(2008). Advances in Critical Care for the Nephrologist: Acute Lung Injury/ARDS. CJASN
3: 578-586
[Abstract][Full Text]
Xu, H., Chu, S.
(2007). ENaC {alpha}-subunit variants are expressed in lung epithelial cells and are suppressed by oxidative stress. Am. J. Physiol. Lung Cell. Mol. Physiol.
293: L1454-L1462
[Abstract][Full Text]
Xu, H., Ferro, T. J., Chu, S.
(2007). Cigarette smoke condensate inhibits ENaC {alpha}-subunit expression in lung epithelial cells. Eur Respir J
30: 633-642
[Abstract][Full Text]
Alvarez, D. F., King, J. A., Weber, D., Addison, E., Liedtke, W., Townsley, M. I.
(2006). Transient Receptor Potential Vanilloid 4-Mediated Disruption of the Alveolar Septal Barrier: A Novel Mechanism of Acute Lung Injury. Circ. Res.
99: 988-995
[Abstract][Full Text]
Uchida, T., Shirasawa, M., Ware, L. B., Kojima, K., Hata, Y., Makita, K., Mednick, G., Matthay, Z. A., Matthay, M. A.
(2006). Receptor for Advanced Glycation End-Products Is a Marker of Type I Cell Injury in Acute Lung Injury. Am. J. Respir. Crit. Care Med.
173: 1008-1015
[Abstract][Full Text]