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Correspondence
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Volume 353:2815-2817 December 29, 2005 Number 26
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Autoantibodies in Prostate Cancer

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 by Wang, X.
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To the Editor: Wang et al. (Sept. 22 issue)1 constructed a 22-phage-peptide detector for prostate cancer, with 81.6 percent sensitivity and 88.2 percent specificity. Previously, we constructed a decision tree for classifying prostate cancer, using five tumor-associated antigens, with 79 percent sensitivity and 86 percent specificity.2 With a smaller panel, these rates are equivalent to those of Wang et al. and might be improved by the selection of other tumor-associated antigens.

Only four peptides in the panel that was developed by Wang et al. were derived from in-frame coding sequences. Whether the other 18 peptides are mimotopes could be determined, . . . [Full Text of this Article]


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