As the obesity pandemic continues to worsen and medical interventionsremain only moderately effective, bariatric surgery is at presentthe only method that reliably results in major, long-term weightloss.1,2 The most successful procedures durably reduce bodyweight by about one third and ameliorate nearly all obesity-relatedcomplications, most notably almost miraculously type 2 diabetes mellitus.2 Not surprisingly, bariatrics is thefastest-growing surgical subspecialty. The number of bariatricsurgeons registered with the American Society for BariatricSurgery increased by almost 50 percent per year during the pastseveral years, and the number of bariatric operations nearlydoubles annually.3. . . [Full Text of this Article]
Source Information
From the Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, and Veterans Affairs Puget Sound Health Care System, Seattle.
Thaler, J. P., Cummings, D. E.
(2009). Hormonal and Metabolic Mechanisms of Diabetes Remission after Gastrointestinal Surgery. Endocrinology
150: 2518-2525
[Abstract][Full Text]
Vidal, J., Nicolau, J., Romero, F., Casamitjana, R., Momblan, D., Conget, I., Morinigo, R., Lacy, A. M.
(2009). Long-Term Effects of Roux-en-Y Gastric Bypass Surgery on Plasma Glucagon-Like Peptide-1 and Islet Function in Morbidly Obese Subjects. J. Clin. Endocrinol. Metab.
94: 884-891
[Abstract][Full Text]
Bult, M. J F, van Dalen, T., Muller, A. F
(2008). Surgical treatment of obesity. Eur J Endocrinol
158: 135-145
[Abstract][Full Text]
Cummings, D. E., Flum, D. R.
(2008). Gastrointestinal Surgery as a Treatment for Diabetes. JAMA
299: 341-343
[Full Text]
Vella, A., Service, F. J.
(2007). Incretin Hypersecretion in Post-Gastric Bypass Hypoglycemia Primary Problem or Red Herring?. J. Clin. Endocrinol. Metab.
92: 4563-4565
[Full Text]
Khoo, T.-K., Service, F. J.
(2006). 47-Year-Old Woman With Spells of Slurred Speech, Blurred Vision, and Loss of Consciousness. Mayo Clin Proc.
81: 1495-1498
[Full Text]
Meier, J. J., Butler, A. E., Galasso, R., Butler, P. C.
(2006). Hyperinsulinemic Hypoglycemia After Gastric Bypass Surgery Is Not Accompanied by Islet Hyperplasia or Increased {beta}-Cell Turnover. Diabetes Care
29: 1554-1559
[Abstract][Full Text]
Carpenter, T., Trautmann, M. E., Baron, A. D., Kaiser, A. M., Service, F. J., Thompson, G. B., Lloyd, R. V., Cummings, D. E., Shannon, M. H., Carlson, M. J.
(2005). Hyperinsulinemic Hypoglycemia with Nesidioblastosis after Gastric-Bypass Surgery. NEJM
353: 2192-2194
[Full Text]