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Volume 353:314-315 July 21, 2005 Number 3
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Thrombosis of the Cerebral Veins and Sinuses

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by Stam, J.
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To the Editor: The review by Stam of thrombosis of the cerebral veins and sinuses (April 28 issue)1 did not include heparin-induced thrombocytopenia as one of the causes of thrombosis. This acquired hypercoagulability state results from the presence of heparin-dependent, platelet-activating IgG antibodies. Cerebral venous or sinus thrombosis occurred in 3 (2.9 percent) of 105 patients and in 7 (1.7 percent) of 408 patients in two studies2,3 involving the clinical presentation of this adverse drug reaction. If sinus thrombosis is suspected in a patient who is currently using or has recently used heparin, heparin-induced thrombocytopenia must be ruled out, since . . . [Full Text of this Article]



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