An examination of the blood smear (or film) may be requestedby physicians or initiated by laboratory staff. With the developmentof sophisticated automated blood-cell analyzers, the proportionof blood-count samples that require a blood smear has steadilydiminished and in many clinical settings is now 10 to 15 percentor less. Nevertheless, the blood smear remains a crucial diagnosticaid. The proportion of requests for a complete blood count thatgenerate a blood smear is determined by local policies and sometimesby financial and regulatory as well as medical considerations.For maximal information to be derived from a blood . . . [Full Text of this Article]
When Physicians Should Request a Blood Smear
Anemia
Hemolytic Anemia
Macrocytic Anemia
Microcytic Anemia
Hemoglobinopathy and Thalassemia
Thrombocytopenia and Thrombocytosis
Leukemia, Lymphoma, or Bone Marrow Failure
Probable Factitious Results
Serendipity
The Blood Smear as Part of the Medical Record
The Future
Conclusions
Source Information
From the Department of Haematology, St. Mary's Hospital, London. Send reprint requests to Dr. Bain at St. Mary's Hospital, Praed St., London W2 1NY, United Kingdom, or at b.bain@imperial.ac.uk. A related slide show is available as a Supplementary Appendix at www.nejm.org.
McLean, R., Jury, C., Bazeos, A., Lewis, S M.
(2009). Application of camera phones in telehaematology. J Telemed Telecare
15: 339-343
[Abstract][Full Text]
Prokocimer, M, Potasman, I
(2008). The added value of peripheral blood cell morphology in the diagnosis and management of infectious diseases--part 1: basic concepts. Postgrad. Med. J.
84: 579-585
[Abstract][Full Text]
van der Meer, W., van Gelder, W., de Keijzer, R., Willems, H.
(2007). The divergent morphological classification of variant lymphocytes in blood smears. J. Clin. Pathol.
60: 838-839
[Full Text]
Aslinia, F., Mazza, J. J., Yale, S. H.
(2006). Megaloblastic anemia and other causes of macrocytosis.. Clin Med Res
4: 236-241
[Full Text]
Steensma, D. P., Bennett, J. M.
(2006). The Myelodysplastic Syndromes: Diagnosis and Treatment. Mayo Clin Proc.
81: 104-130
[Abstract][Full Text]
Sill, H., Neubauer, M., Lawrence, C.
(2005). Diagnosis from the blood smear.. NEJM
353: 1862-1862
[Full Text]