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Previous Volume 353:522-523 August 4, 2005 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The study of degenerative diseases is often neglected by basic scientists, probably because these complicated pathophysiological conditions are considered to be mere consequences of aging. But there is an urgent need to understand the fundamental mechanism of these diseases, thus allowing the rational development of therapies. Mouse models provide a way to identify otherwise elusive mechanisms of disease because they allow us to determine the in vivo function of a given protein in a given type of cell at a particular time. A pair of recent studies by Stanton and colleagues¹ and Glasson and colleagues² realizes this goal in the . . . [Full Text of this Article]

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From the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston.

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