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Correction to Ito et al., N Engl J Med 352(19):1967-1976 May 12, 2005.

Correspondence
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Volume 353:528-529 August 4, 2005 Number 5
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Histone Deacetylase Activity and COPD

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by Ito, K.
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To the Editor: In their study, Ito and colleagues (May 12 issue)1 observed reductions in both the activity and expression of histone deacetylases (HDACs), especially HDAC2, in patients with chronic obstructive pulmonary disease (COPD). In addition, the activity inversely correlated with the severity of COPD.

Histone-modifying enzymes play essential roles in gene regulation.2 The balance between histone acetylation and deacetylation appears to be crucial to normal cell growth. Disruption of either of these molecular mechanisms has been associated with the development of cancer. Several molecules and genes have been identified or developed or both to inhibit HDACs.3 Valproic acid, an . . . [Full Text of this Article]



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