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Volume 353:738-739 August 18, 2005 Number 7
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Asthma and Invasive Pneumococcal Disease

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 by Talbot, T. R.
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To the Editor: Talbot et al.1 (May 19 issue) find that in the absence of coexisting conditions such as diabetes, alcoholism, or infection with HIV, which are known to confer a high risk of invasive pneumococcal disease, the excess presence of invasive pneumococcal disease among persons with asthma is one to three episodes per 10,000 person-years. The presence of coexisting conditions was determined from hospital and pharmacy records for the year before the index date, defined as the date of isolation of Streptococcus pneumoniae. However, HIV infection often goes undetected, even in patients receiving medical care,2 until a known . . . [Full Text of this Article]




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