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Previous Volume 353:924-932 September 1, 2005 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Dengue virus infection is increasingly recognized as one of the world's major emerging infectious diseases.^1,2,3 Dengue is endemic in most tropical and subtropical countries, many of which are popular tourist destinations.⁴ International travelers may both acquire and spread dengue virus infection. Health care providers need to understand the epidemiology, risk factors, clinical spectrum, diagnosis, management, and prevention of dengue in travelers.

The Virus, the Vector, and the Epidemiology of Dengue

Dengue virus belongs to the family Flaviviridae (single-stranded, nonsegmented RNA viruses) (Table 1) and has four serologically distinct serotypes (DEN-1, DEN-2, DEN-3, and DEN-4).¹ Dengue virus serotypes are distinguishable by complement-fixation and neutralization tests.⁵ Infection with one . . . [Full Text of this Article]

Risk among International Travelers

Clinical Aspects of Dengue Virus Infections

Pathogenesis

Asymptomatic Infection and Acute Febrile Illness

Classic Dengue Fever

Dengue Hemorrhagic Fever and Dengue Shock Syndrome

Diagnosis and Differential Diagnosis

Management

Prevention of Dengue Infections in Travelers

Source Information

From the Travellers' Health and Vaccination Centre, Tan Tock Seng Hospital, Singapore (A.W.-S.); and the Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, Tel Hashomer, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv — both in Israel (E.S.).

Address reprint requests to Dr. Wilder-Smith at the Travellers' Health and Vaccination Centre, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, or at epvws@pacific.net.sg.

Related Letters:

Dengue in Travelers
Seligman S. J., Kramer L. D., Roesel T. R., Saxena A. K., Wilder-Smith A., Schwartz E.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:2511-2513, Dec 8, 2005. Correspondence

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