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Know syphilis, and you will know all of medicine, advised Sir William Osler at the turn of the 20th century. In that era, the pervasive consequences of syphilis deeply involved specialties from neurology to cardiology to orthopedics, as well as a large proportion of the population. Beyond clinical medicine, responding to syphilis became the central organizing focus of public health, and the fundamental systems of disease control and prevention that have operated for most health conditions until today have been conditioned around the response to this one overriding epidemic.
The global pandemic of HIV and AIDS is now having similar
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