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Previous Volume 354:75-77 January 5, 2006 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Rotavirus disease kills approximately half a million children annually in developing countries and accounts for one third of hospitalizations for diarrhea worldwide.¹ In 1999, global efforts to control the tremendous health burden of gastroenteritis suffered an abrupt and unanticipated setback. The first licensed rotavirus vaccine (RotaShield) was withdrawn from the U.S. market less than a year after its introduction because it was associated with an uncommon but potentially life-threatening adverse event, intussusception, at an estimated rate of 1 incident per 10,000 vaccine recipients.²

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View larger version (101K): [in this window] [in a new window]   Figure 1. Negative-Stain Electron Micrograph of Rotavirus A. The virus is 70 to 75 nm in . . . [Full Text of this Article]

 

Source Information

From the Centers for Disease Control and Prevention, Atlanta.

Related Letters:

Rotavirus Vaccines
Molinaro G. A., Lee D. A., Lee P.-I., Simonsen L., Taylor R. J., Kapikian A. Z., Ruiz L. P. Jr., O'Ryan M., Ruiz-Palacios G. M., Clemens R., Vesikari T., DiNubile M. J., Heaton P. M., Glass R. I., Parashar U. D.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:1747-1751, Apr 20, 2006. Correspondence

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