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Previous Volume 354:88-90 January 5, 2006 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Drumm and colleagues (Oct. 6 issue)¹ identified sequence variants in the TGF1 gene as genetic modifiers of lung disease in cystic fibrosis. TGF1 is encoded on chromosome 19q13, 4.5 Mbp from the CFM1 locus that confers a risk of meconium ileus.² We scanned this region on 19q13 with use of single-nucleotide polymorphisms (SNPs) and microsatellites in a cohort of sibling pairs homozygous for the F508 mutation with extreme clinical phenotypes³ for a modulator of disease severity. Neither the two TGF1 SNPs (–509 and codon 10)¹ nor the microsatellite D19S112 at CFM1² was associated with . . . [Full Text of this Article]

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