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Correspondence
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Volume 354:90-94 January 5, 2006 Number 1
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Antibacterial Prophylaxis in Patients with Cancer and Neutropenia

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 by Baden, L. R.
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 by Cullen, M.
-PubMed Citation
To the Editor: The recent studies by Bucaneve et al.1 and Cullen et al.2 (Sept. 8 issue) suggest that many patients with cancer and neutropenia may benefit from levofloxacin prophylaxis. Although the reports were published in tandem, their clinical implications differ fundamentally. Bucaneve et al. targeted "high-risk" patients (stem-cell transplant recipients or patients with leukemia) with anticipated neutropenia lasting more than seven days, a previously accepted approach.3

In contrast, most patients studied by Cullen et al. had solid tumors. Because patients with such tumors are unlikely to have prolonged or profound neutropenia, they are at lower risk for infectious complications.4 . . . [Full Text of this Article]




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