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Volume 354:1318-1320 March 23, 2006 Number 12
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Beta-Blockers to Prevent Gastroesophageal Varices in Cirrhosis

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by Groszmann, R. J.
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To the Editor: The report by Groszmann et al. (Nov. 24 issue)1 answers a question my colleagues and I first raised several years ago2 — namely, that of the potential value of nonselective beta-blockade in the treatment of unselected patients with cirrhosis. We hypothesized that the use of nonselective beta-blockers would lead to a lower rate of esophageal variceal hemorrhage, death, or both, if these agents were given to all such patients.

With regard to the study by Groszmann et al., the classification of a therapy-induced drop in the heart rate to below 50 beats per minute as a serious . . . [Full Text of this Article]



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