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Previous Volume 354:1758-1759 April 20, 2006 Number 16 Next

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To the Editor: Asymptomatic carriers of human T-cell lymphotropic virus type I (HTLV-I) are considered acceptable as donors in allogeneic stem-cell transplantation for patients with adult T-cell leukemia–lymphoma (ATL).¹ However, the infusion of HTLV-I–infected cells from HTLV-I–seropositive donors could lead to the development of donor-derived ATL under immunosuppressive conditions after stem-cell transplantation. Here we describe a patient in whom ATL derived from donor cells developed four months after transplantation of stem cells from a sibling with HTLV-I.

A 44-year-old Japanese man with lymphoma-type ATL underwent transplantation of bone marrow from his HLA-identical brother in February 2004. The conditioning regimen included . . . [Full Text of this Article]

Related Letters:

More on Donor-Derived T-Cell Leukemia after Bone Marrow Transplantation
Focosi D., Petrini M., Tamaki H., Matsuoka M.
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N Engl J Med 2006; 355:212-213, Jul 13, 2006. Correspondence

This article has been cited by other articles:

• Focosi, D., Petrini, M., Tamaki, H., Matsuoka, M. (2006). More on donor-derived T-cell leukemia after bone marrow transplantation.. NEJM 355: 212-213 [Full Text]