The acute respiratory distress syndrome (ARDS) is characterizedby inflammatory lung injury with alveolar flooding and abnormalitiesin surfactant function. ARDS (a subcategory of acute lung injury)is associated with the collapse of peripheral lung units, pulmonaryinfiltrates, stiff lungs, and hypoxemia.1 The syndrome is bothcommon (with an incidence of about 80 cases per 100,000 populationevery year) and lethal (with a death rate of more than 38 percent)in a community population of patients with acute lung injury.2
Patients with severe ARDS invariably require mechanical ventilationto decrease the work of breathing and to improve oxygen transport.An . . . [Full Text of this Article]
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From the Departments of Medicine and Critical Care Medicine, St. Michael's Hospital; and the Interdepartmental Division of Critical Care Medicine, University of Toronto both in Toronto (A.S.); and the Department of Medicine, University of Washington, Seattle (L.H.).
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