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Previous Volume 354:1848-1851 April 27, 2006 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Ratjen, F. Related Article by Elkins, M. R. Related Article by Donaldson, S. H. PubMed Citation

To the Editor: We question the selection by Elkins et al.¹ and Donaldson et al.² (Jan. 19 issue) of 7 percent hypertonic saline, which can result in bronchoconstriction, in these studies of therapy for cystic fibrosis. Elkins et al. report a fall of 94 ml in the forced expiratory volume in one second (FEV₁) after the first dose of medication, which is greater than the reported final improvement in FEV₁ of 68 ml. Conversely, Donaldson et al. do not specify any change in FEV₁ with the use of 7 percent hypertonic saline. Robinson et al.³ have compared mucociliary clearance . . . [Full Text of this Article]

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• Kuver, R., Wong, T., Klinkspoor, J. H., Lee, S. P. (2006). Absence of CFTR is associated with pleiotropic effects on mucins in mouse gallbladder epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G1148-G1154 [Abstract] [Full Text]