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Previous Volume 354:1961-1963 May 4, 2006 Number 18 Next

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To the Editor: Focal segmental glomerulosclerosis recurs in about 30 percent of patients who undergo kidney transplantation for this condition and leads to the nephrotic syndrome and accelerated graft loss.¹ Cyclosporine, cyclophosphamide, plasmapheresis, protein A immunoabsorption, and mycophenolate mofetil have been variably effective.^1,2

We report the case of a seven-year-old boy who presented with immediate recurrence of focal segmental glomerulosclerosis after transplantation that subsequently resolved only after rituximab treatment of a transplantation-related lymphoma that occurred five months after the surgery. This child originally had biopsy-proven primary focal segmental glomerulosclerosis with the nephrotic syndrome. After 4.5 years, he progressed to renal . . . [Full Text of this Article]

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• Coppo, R. (2008). Non-steroidal and non-cytotoxic therapies for nephrotic syndrome. Nephrol Dial Transplant 23: 1793-1796 [Full Text]  
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