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Previous Volume 354:2034-2045 May 11, 2006 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hematopoiesis is the process that generates blood cells of all lineages. Calculations based on the blood volume and the level and half-life of each type of blood cell in the circulation indicate that each day an adult produces approximately 200 billion erythrocytes, 100 billion leukocytes, and 100 billion platelets. Moreover, these rates can increase by a factor or 10 or more when the demand for blood cells increases.

In 1906, Carnot¹ found that injecting healthy rabbits with serum from anemic animals prompted a rapid increase of erythrocytes in the recipients. The responsible humoral substance was first termed "hemopoietine" and was . . . [Full Text of this Article]

Lineage-Specific Hematopoietic Growth Factors

Erythropoietin

Granulocyte Colony-Stimulating Factor

Thrombopoietin

Hematopoietic Growth Factor Receptors

Forms of and Clinical Uses for Hematopoietic Growth Factors

Erythropoietin

G-CSF

Thrombopoietin

Conclusions

Source Information

From the Department of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego.

Address reprint requests to Dr. Kaushansky at 402 Dickinson St., Suite 380, San Diego, CA 92103-8811.

Related Letters:

Lineage-Specific Hematopoietic Growth Factors
Ferretti G., Papaldo P., Cognetti F., Dale D. C., Rosenberg P. S., Alter B. P., Kaushansky K.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:526-527, Aug 3, 2006. Correspondence

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