FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 354:2034-2045 May 11, 2006 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Hematopoiesis is the process that generates blood cells of all lineages. Calculations based on the blood volume and the level and half-life of each type of blood cell in the circulation indicate that each day an adult produces approximately 200 billion erythrocytes, 100 billion leukocytes, and 100 billion platelets. Moreover, these rates can increase by a factor or 10 or more when the demand for blood cells increases.

In 1906, Carnot¹ found that injecting healthy rabbits with serum from anemic animals prompted a rapid increase of erythrocytes in the recipients. The responsible humoral substance was first termed "hemopoietine" and was . . . [Full Text of this Article]

Lineage-Specific Hematopoietic Growth Factors

Erythropoietin

Granulocyte Colony-Stimulating Factor

Thrombopoietin

Hematopoietic Growth Factor Receptors

Forms of and Clinical Uses for Hematopoietic Growth Factors

Erythropoietin

G-CSF

Thrombopoietin

Conclusions

Source Information

From the Department of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego.

Address reprint requests to Dr. Kaushansky at 402 Dickinson St., Suite 380, San Diego, CA 92103-8811.

Related Letters:

Lineage-Specific Hematopoietic Growth Factors
Ferretti G., Papaldo P., Cognetti F., Dale D. C., Rosenberg P. S., Alter B. P., Kaushansky K.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:526-527, Aug 3, 2006. Correspondence

This article has been cited by other articles:

• Pozner, R., Schattner, M. (2008). TPO signaling: when the tyrosines go marching in(side). Blood 112: 2171-2172 [Full Text]  
• Courneya, K. S., Jones, L. W., Peddle, C. J., Sellar, C. M., Reiman, T., Joy, A. A., Chua, N., Tkachuk, L., Mackey, J. R. (2008). Effects of Aerobic Exercise Training in Anemic Cancer Patients Receiving Darbepoetin Alfa: A Randomized Controlled Trial. The Oncologist 13: 1012-1020 [Abstract] [Full Text]  
• Hamada, T., Matsuura, H., Oono, T., Morizane, S., Yamasaki, O., Asagoe, K., Yamamoto, T., Tsuji, K., Iwatsuki, K. (2008). Karyotypic Analysis of Bone Marrow Cells in Pyodermic Lesions Associated With Myelodysplastic Syndrome. Arch Dermatol 144: 643-648 [Abstract] [Full Text]  
• Liu, K., Kralovics, R., Rudzki, Z., Grabowska, B., Buser, A. S., Olcaydu, D., Gisslinger, H., Tiedt, R., Frank, P., Okon, K., van der Maas, A. P.C., Skoda, R. C. (2008). A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family. haematol 93: 706-714 [Abstract] [Full Text]  
• Tong, Q., Hirschler-Laszkiewicz, I., Zhang, W., Conrad, K., Neagley, D. W., Barber, D. L., Cheung, J. Y., Miller, B. A. (2008). TRPC3 Is the Erythropoietin-regulated Calcium Channel in Human Erythroid Cells. J. Biol. Chem. 283: 10385-10395 [Abstract] [Full Text]  
• Luc, S., Anderson, K., Kharazi, S., Buza-Vidas, N., Boiers, C., Jensen, C. T., Ma, Z., Wittmann, L., Jacobsen, S. E. W. (2008). Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential. Blood 111: 3424-3434 [Abstract] [Full Text]  
• Verstovsek, S., Manshouri, T., Quintas-Cardama, A., Harris, D., Cortes, J., Giles, F. J., Kantarjian, H., Priebe, W., Estrov, Z. (2008). WP1066, a Novel JAK2 Inhibitor, Suppresses Proliferation and Induces Apoptosis in Erythroid Human Cells Carrying the JAK2 V617F Mutation. Clin. Cancer Res. 14: 788-796 [Abstract] [Full Text]  
• Italiano, J. E. Jr (2008). Megakaryocyte and platelet biology: getting your FAKs straight. Blood 111: 482-483 [Full Text]  
• Bodo, E., Kromminga, A., Funk, W., Laugsch, M., Duske, U., Jelkmann, W., Paus, R. (2007). Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB J. 21: 3346-3354 [Abstract] [Full Text]  
• Hibbs, M. L., Quilici, C., Kountouri, N., Seymour, J. F., Armes, J. E., Burgess, A. W., Dunn, A. R. (2007). Mice Lacking Three Myeloid Colony-Stimulating Factors (G-CSF, GM-CSF, and M-CSF) Still Produce Macrophages and Granulocytes and Mount an Inflammatory Response in a Sterile Model of Peritonitis. J. Immunol. 178: 6435-6443 [Abstract] [Full Text]  
• Horwitz, M. S., Duan, Z., Korkmaz, B., Lee, H.-H., Mealiffe, M. E., Salipante, S. J. (2007). Neutrophil elastase in cyclic and severe congenital neutropenia. Blood 109: 1817-1824 [Abstract] [Full Text]  
• Touw, I. P., Bontenbal, M. (2007). Granulocyte Colony-Stimulating Factor: Key (F)actor or Innocent Bystander in the Development of Secondary Myeloid Malignancy?. JNCI J Natl Cancer Inst 99: 183-186 [Full Text]  
• Hershman, D., Neugut, A. I., Jacobson, J. S., Wang, J., Tsai, W.-Y., McBride, R., Bennett, C. L., Grann, V. R. (2007). Acute Myeloid Leukemia or Myelodysplastic Syndrome Following Use of Granulocyte Colony-Stimulating Factors During Breast Cancer Adjuvant Chemotherapy. JNCI J Natl Cancer Inst 99: 196-205 [Abstract] [Full Text]  
• Ferretti, G., Papaldo, P., Cognetti, F., Dale, D. C., Rosenberg, P. S., Alter, B. P., Kaushansky, K. (2006). Lineage-specific hematopoietic growth factors.. NEJM 355: 526-527 [Full Text]