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Previous Volume 354:2060-2062 May 11, 2006 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The characteristics of renal allografts before transplantation present a multifaceted puzzle that in large part predetermines the outcome of kidney transplantation. Compatibility at the major-histocompatibility-complex (MHC) loci, the age of the donor, cold-ischemia times, and nephron mass^1,2 all contribute to long-term results through interacting effects involving initial damage to parenchymal or vascular cells and possible hyperfiltration. Many factors are involved in chronic allograft dysfunction, in which immune-mediated lesions caused by chronic rejection are only one component.³

In this issue of the Journal, Brown et al.⁴ report on a newly identified donor factor, an allotype of the C3 complement molecule that . . . [Full Text of this Article]

Source Information

From the Centre Hospitalier Universitaire de Nantes and INSERM Unité 643 (J.-P.S., M.G.) and Université de Nantes (J.-P.S.) — all in Nantes, France.

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