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Previous Volume 354:2067-2068 May 11, 2006 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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"There is no disease more conducive to clinical humility than aneurysm of the aorta." These words of Sir William Osler still resonate today, when many patients with ruptured abdominal aortic aneurysms die before reaching the hospital and the mortality rate among those who reach the hospital can exceed 50 percent. The prevention of rupture through early detection and elective repair remains the standard therapy. A recent study by Yoshimura et al.,¹ however, suggests the possibility of pharmacologic therapy.

Researchers have found that the degradation of the extracellular-matrix proteins elastin and collagen in the aortic wall is critical to the pathogenesis . . . [Full Text of this Article]

Source Information

From the University of Toronto, Toronto.

This article has been cited by other articles:

• Kuivaniemi, H., Platsoucas, C. D., Tilson, M. D. III (2008). Aortic Aneurysms: An Immune Disease With a Strong Genetic Component. Circulation 117: 242-252 [Full Text]