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Previous Volume 354:189-191 January 12, 2006 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Hou and colleagues¹ present data indicating that the use of benazepril, an angiotensin-converting–enzyme (ACE) inhibitor, is feasible and beneficial in patients with advanced chronic kidney disease, a point that has been much debated. This clinical trial in China, which confirms pilot data from the same group,² provides some clarity, demonstrating that ACE inhibitors can be administered in generous doses, even in patients with stage 4 chronic kidney disease, as defined by a glomerular filtration rate (GFR) of 15 to 29 ml per minute per 1.73 m² and a serum creatinine level of approximately 3.0 . . . [Full Text of this Article]

Source Information

From Ohio State University Medical Center, Columbus.

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• Bloom, J. M., Jaber, B. L., Madias, N. E., Hou, F. F., Zhang, X. (2006). Benazepril for advanced chronic renal insufficiency.. NEJM 354: 1530-1531 [Full Text]  
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