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Previous Volume 354:209-210 January 12, 2006 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Lamin A/C gene mutations are associated with various disorders,^1,2 including cardiac abnormalities characterized by atrial fibrillation, conduction-system disturbances, sudden death, and heart failure.^3,4 In retrospective analyses, we have previously investigated the high incidence of sudden death among carriers of such mutations.^4,5 Although there is consensus regarding the efficacy of implantable cardioverter–defibrillators (ICDs) in the secondary prevention of sudden death in persons with cardiovascular disease and also in primary prevention in patients with a reduced ejection fraction (<35 percent), it is not yet known whether ICD therapy is efficacious as primary prevention in carriers of a lamin A/C . . . [Full Text of this Article]

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