Hearing loss is an etiologically heterogeneous trait with manyknown genetic and environmental causes.1 Historically, someenvironmental causes of hearing loss, such as rubella embryopathy,have been epidemic in nature, establishing that the incidenceof congenital deafness can vary widely at various times andamong populations. Other important environmental causes of hearingloss include prematurity, prenatal and postnatal infections,head trauma, subarachnoid hemorrhage, and pharmacologic ototoxicity.Genetic causes account for at least 50 to 60 percent of childhoodhearing loss in developed countries and can be classified accordingto the pattern of inheritance, the presence (syndromic) or absence(nonsyndromic) of . . . [Full Text of this Article]
Prevalence of Hearing Loss in Newborns
Limitations of Existing Screening Programs
Genetic Causes of Syndromic Hearing Loss
Genetic Causes of Nonsyndromic Hearing Loss
Cause of the High Prevalence of Deafness from Mutations in GJB2
Environmental Causes of Prelingual Hearing Loss
Improving Detection of Late-Onset Prelingual Hearing Loss
Source Information
From the Departments of Obstetrics, Gynecology, and Reproductive Biology and Pathology, Brigham and Women's Hospital and Harvard Medical School — both in Boston (C.C.M.); and the Department of Human Genetics, Pediatrics, Medicine, and Otolaryngology, Medical College of Virginia, Virginia Commonwealth University, Richmond (W.E.N.).
Address reprint requests to Dr. Nance at the Department of Human Genetics, Sanger Hall, 11th floor, 1101 E. Marshall St., P.O. Box 980033, Richmond, VA 23298-0033, or at nance@mail2.vcu.edu.
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