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Previous Volume 354:2191-2193 May 18, 2006 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the excellent review of drug-related hepatotoxicity by Navarro and Senior (Feb. 16 issue),¹ antithyroid agents were not included in the authors' list of medications that cause injury to the liver. Both classes of antithyroid agents, propylthiouracil and methimazole, are known rarely to cause liver dysfunction, which is among the small number of their idiosyncratic toxic effects. The antithyroid drugs have distinct patterns of injury: propylthiouracil has hepatocellular toxic effects and methimazole induces cholestasis.² The severity of these toxic effects ranges from elevated levels of enzymes without permanent injury to fulminant hepatic failure leading to liver transplantation.³ . . . [Full Text of this Article]

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