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Previous Volume 354:2193-2194 May 18, 2006 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The sensitivity of lung cancer to gefitinib has been found to be associated with mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR),^1,2,3 yet similar observations are not available for other solid tumors.⁴ We investigated whether gefitinib-sensitizing mutations in the EGFR gene were present in human esophageal tumors.

DNA that was isolated from fresh-frozen tissue from 87 specimens of primary esophageal carcinoma — which included 20 specimens of dysplasia, 10 of primary esophageal adenocarcinoma, and 57 of primary esophageal squamous-cell carcinoma — were screened for mutations in EGFR gene exons 18 through 21 by . . . [Full Text of this Article]

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