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Previous Volume 354:2392 June 1, 2006 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We have three questions for Holtmann et al. (Feb. 23 issue).¹ First, could they clarify the methods used to determine Helicobacter pylori status — that is, was the gold-standard combination of histologic analysis, culture, and rapid urease testing of gastric-biopsy specimens used?²

Second, was there control for cigarette smoking or the use of aspirin or nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs)? We appreciate that the association between these factors and functional dyspepsia is controversial,^3,4 but dyspeptic symptoms have been linked to smoking and the use of NSAIDs and aspirin.^3,5

Finally, the mean ages were similar among the four . . . [Full Text of this Article]

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