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Previous Volume 354:2495-2498 June 8, 2006 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Two articles in this issue of the Journal, by Dave et al.¹ and Hummel et al.,² report on the use of gene-expression microarray technology to improve the accuracy of the diagnosis of Burkitt's lymphoma. The two studies differ in many important ways, but both reach the same conclusion: the gene-expression profiling of cases classified as Burkitt's lymphoma by expert pathologists identifies a characteristic genetic signature that clearly distinguishes this tumor from cases of diffuse large-B-cell lymphoma. Furthermore, the microarray method seems to outperform the expert pathologists: 17 percent¹ and 34 percent² of cases with the gene-expression signature of Burkitt's lymphoma . . . [Full Text of this Article]

Source Information

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School — both in Boston (N.L.H.); and the Oncology Division, Department of Medicine, Stanford Medical School, Stanford, Calif. (S.J.H.).

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