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Volume 354:2509-2511 June 8, 2006 Number 23
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Delirium in Older Persons

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by Inouye, S. K.
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To the Editor: In her review article about delirium in older persons (March 16 issue),1 Inouye mentions anticholinergic drugs, which are associated with an increased risk of delirium. Many commonly prescribed drugs have anticholinergic effects.2 Ophthalmic medications containing anticholinergic agents are frequently overlooked as a cause of delirium.3,4 Cycloplegic and mydriatic agents (including eyedrops containing anticholinergic drugs, such as atropine and cyclopentolate) are frequently prescribed for elderly persons. Systemic side effects (which are mainly cerebellar or cerebral and include visual and tactile hallucinations, incoherent speech, agitation, disorientation, memory loss, and acute psychotic reactions) have been described after topical administration of . . . [Full Text of this Article]



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