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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the authors' clinical recommendations.
A 16-year-old boy with a 15-year history of asthma from the age of one year and two visits to the emergency department in the past year presents for evaluation. He reports symptoms consistent with those of severe persistent asthma
The Clinical Problem
Treatment
Effect of Therapy with Omalizumab
Evidence of a Clinical Benefit
Clinical Use
Preparation for Use
Cost
Response to Treatment
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Department of Pediatrics, Washington University School of Medicine, St. Louis.
Related Letters:
Omalizumab for Asthma
Winchester D. E., Jacob A., Murphy T., Tonnel A.-B., Tillie-Leblond I.
Extract |
Full Text |
PDF
N Engl J Med 2006;
355:1281-1282, Sep 21, 2006.
Correspondence
This article has been cited by other articles:
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