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Previous Volume 354:2709-2711 June 22, 2006 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Scleroderma (systemic sclerosis) is characterized by the deposition and accumulation of excessive amounts of collagen and extracellular-matrix molecules, the dysfunction of microvascular endothelial cells, and altered immune tolerance. These interacting and interdependent processes lead to chronic inflammation and tissue fibrosis.

To investigate complex mechanisms of disease pathogenesis, conventional wisdom dictates that a single aspect of disease be dissected out and examined in detail. The skin is a prominent target organ in scleroderma, and fibroblasts from affected patients are activated and display a variety of properties, including increased production of collagens and other extracellular-matrix proteins, abnormal growth patterns, and resistance to . . . [Full Text of this Article]

Source Information

From the Department of Internal Medicine, Division of Rheumatology, University of Texas Medical School at Houston.

Related Letters:

Stimulatory Autoantibodies to the PDGF Receptor in Scleroderma
Okamoto H., Lozano E., Segarra M., Cid M. C., Gabrielli A., Baroni S. S., Avvedimento E. V., Tan F. K.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:1278-1280, Sep 21, 2006. Correspondence

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• Kapur, R., Ebeling, S., Hagenbeek, A. (2008). B-cell involvement in chronic graft-versus-host disease. haematol 93: 1702-1711 [Abstract] [Full Text]  
• Okamoto, H., Lozano, E., Segarra, M., Cid, M. C., Gabrielli, A., Baroni, S. S., Avvedimento, E. V., Tan, F. K. (2006). Stimulatory autoantibodies to the PDGF receptor in scleroderma.. NEJM 355: 1278-1278 [Full Text]