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Volume 354:2725-2726 June 22, 2006 Number 25
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Gatifloxacin and Dysglycemia in Older Adults

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by Park-Wyllie, L. Y.
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To the Editor: Park-Wyllie and colleagues (March 30 issue)1 advise avoiding the use of gatifloxacin because of the increased risk of dysglycemia, and they suggest using alternative antibiotics, including other fluoroquinolones, that confer little or no increased risk of dysglycemia. This suggestion must be questioned. Although it appears that the administration of moxifloxacin has no clinically relevant effect on blood glucose homeostasis,2 other fluoroquinolones may trigger dysglycemic events, especially in patients with diabetes who receive sulfonylureas.3 Clinicians should be aware of the possibility of dysglycemic events in patients receiving fluoroquinolones.


Karl P. Ittner, M.D., D.E.A.A.
University of Regensburg
D-93042 Regensburg, . . . [Full Text of this Article]



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