FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 354:2815-2817 June 29, 2006 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Barnetson, R. A. PubMed Citation

This year, colorectal cancer will strike about 150,000 people in the United States and 500,000 worldwide. Much of the morbidity and mortality of the disease could be prevented if we knew more about the risk of colorectal cancer developing and were able to take effective preemptive action.

About 3 to 4 percent of cases of colorectal cancer occur in the familial cancer syndromes. The commonest of these is the Lynch syndrome (also called hereditary nonpolyposis colorectal cancer), which is caused by a germ-line mutation in one of four DNA mismatch-repair genes.¹ The identification of patients with the Lynch syndrome is . . . [Full Text of this Article]

Source Information

From the Division of Gastroenterology, Baylor University Medical Center, Dallas.

This article has been cited by other articles:

• Niemela, A. M., Hynninen, P., Mecklin, J.-P., Kuopio, T., Kokko, A., Aaltonen, L., Parkkila, A.-K., Pastorekova, S., Pastorek, J., Waheed, A., Sly, W. S., Orntoft, T. F., Kruhoffer, M., Haapasalo, H., Parkkila, S., Kivela, A. J. (2007). Carbonic Anhydrase IX Is Highly Expressed in Hereditary Nonpolyposis Colorectal Cancer. Cancer Epidemiol. Biomarkers Prev. 16: 1760-1766 [Abstract] [Full Text]