FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 354:2834-2835 June 29, 2006 Number 26 Next

1,3--D-Glucan in Patients Receiving Intravenous Amoxicillin–Clavulanic Acid

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

To the Editor: The fungal component 1,3--D-glucan is increasingly used to diagnose opportunistic invasive mycoses in immunocompromised patients.^1,2,3 The 1,3--D-glucan assay (Fungitell, Associates of Cape Cod) was recently approved by the Food and Drug Administration. We found that the serum samples from two patients with hematologic conditions were positive for 1,3--D-glucan during treatment with intravenous amoxicillin–clavulanic acid. Serum samples were negative after treatment was discontinued. Neither patient had evidence of invasive fungal disease. Furthermore, 1,3--D-glucan was detected in the amoxicillin–clavulanic acid used to treat these patients.

We then tested 10 serum samples from six patients treated . . . [Full Text of this Article]

This article has been cited by other articles:

• Huang, Y.-T., Hung, C.-C., Liao, C.-H., Sun, H.-Y., Chang, S.-C., Chen, Y.-C. (2007). Detection of Circulating Galactomannan in Serum Samples for Diagnosis of Penicillium marneffei Infection and Cryptococcosis among Patients Infected with Human Immunodeficiency Virus. J. Clin. Microbiol. 45: 2858-2862 [Abstract] [Full Text]  
• Kikkert, R., Bulder, I., de Groot, E. R., Aarden, L. A., Finkelman, M. A. (2007). Potentiation of Toll-like receptor-induced cytokine production by (1->3)-{beta}-D-glucans: implications for the monocyte activation test. Innate Immunity 13: 140-149 [Abstract]  
• Marty, F. M., Lowry, C. M., Lempitski, S. J., Kubiak, D. W., Finkelman, M. A., Baden, L. R. (2006). Reactivity of (1->3)-{beta}-D-Glucan Assay with Commonly Used Intravenous Antimicrobials.. Antimicrob. Agents Chemother. 50: 3450-3453 [Abstract] [Full Text]