FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 354:291-293 January 19, 2006 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Elkins, M. R. Related Article by Donaldson, S. H. PubMed Citation

The current pathophysiological model of cystic fibrosis lung disease assumes that defective expression, trafficking, or function of the cystic fibrosis transmembrane regulator (CFTR) protein leads to impaired epithelial chloride secretion and sodium hyperabsorption. This process, in turn, results in the depletion of airway surface liquid and abnormal mucociliary transport. Retention of mucus is thought to favor bacterial overgrowth, which then triggers a cycle of repeated or chronic infections associated with intense neutrophilic airway inflammation.

Defective mucociliary transport itself can cause airway inflammation, as has been shown in mice that have an overexpression of the beta subunit of the epithelial sodium . . . [Full Text of this Article]

Source Information

From the Hospital for Sick Children and the University of Toronto, Toronto.

Related Letters:

Hypertonic Saline for Cystic Fibrosis
Aziz I., Kastelik J. A., Zarogiannis S., Hatzoglou C., Gourgoulianis K., Kuver R., Lee S. P., Bye P. T.P., Elkins M. R., Donaldson S. H., Tarran R., Boucher R. C., Ratjen F.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:1848-1851, Apr 27, 2006. Correspondence

This article has been cited by other articles:

• Song, Y., Namkung, W., Nielson, D. W., Lee, J.-W., Finkbeiner, W. E., Verkman, A. S. (2009). Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L1131-L1140 [Abstract] [Full Text]  
• Taylor, L. M, Kuhn, R. J (2007). Hypertonic Saline Treatment of Cystic Fibrosis. The Annals of Pharmacotherapy 41: 481-484 [Abstract] [Full Text]  
• Aziz, I., Kastelik, J. A., Zarogiannis, S., Hatzoglou, C., Gourgoulianis, K., Kuver, R., Lee, S. P., Bye, P. T.P., Elkins, M. R., Donaldson, S. H., Tarran, R., Boucher, R. C., Ratjen, F. (2006). Hypertonic saline for cystic fibrosis.. NEJM 354: 1848-1851 [Full Text]  
• (2006). Hypertonic Saline for Cystic Fibrosis Patients. JWatch General 2006: 2-2 [Full Text]