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Previous Volume 354:293-295 January 19, 2006 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The first description of a kindred with hereditary nonpolyposis colorectal cancer (HNPCC) in 1925 was based on the family history of a woman who later died from endometrial cancer. On the basis of a detailed interview by Michigan pathologist Aldred Scott Warthin with this woman (his seamstress) and with other members of "Family G," Warthin described a large kindred with hereditary colorectal and endometrial cancers.¹ Sixty-eight years later, Henry Lynch broadened the spectrum of hereditary cancers in the HNPCC syndrome to include ovarian cancer, transitional-cell cancer of the renal pelvis, and less often, stomach, small-intestine, pancreatic, and other types of . . . [Full Text of this Article]

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From the Memorial Sloan-Kettering Cancer Center, New York.

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