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Volume 354:298-300 January 19, 2006 Number 3
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Antipsychotic Drugs and Schizophrenia

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 by Lieberman, J. A.
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To the Editor: The report by Lieberman and colleagues (Sept. 22 issue)1 on the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), funded by the National Institute of Mental Health, raises some questions that require clarification. One can see from the results that olanzapine and perphenazine, which were superior with respect to the rate of discontinuation of treatment, were given in rather high doses, as compared with the doses used in an observational study.2 In contrast, the antipsychotic drugs that were discontinued mainly because of a lack of efficacy, quetiapine and ziprasidone, were given in doses that were rather low (for . . . [Full Text of this Article]


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