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Volume 354:300-303 January 19, 2006 Number 3
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Vasodilators in Aortic Regurgitation

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by Evangelista, A.
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To the Editor: In the study by Evangelista et al. regarding long-term vasodilator therapy in patients with severe aortic regurgitation (Sept. 29 issue),1 both nifedipine and enalapril failed to induce adequate vasodilation, because systolic blood pressure and diastolic blood pressure did not change significantly between baseline and follow-up among patients taking either drug. Therefore, it is not surprising that neither nifedipine nor enalapril improved the outcome of reducing or delaying the need for aortic-valve replacement.2 A reduction in the end-systolic volume or an increase in the ejection fraction, neither of which was seen in this trial, would have been expected . . . [Full Text of this Article]



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