Neurons are extremely sensitive cells, whose function, likethat of all cells, can be influenced by changes in their environment.Using pumps to regulate the internal and external electrolytemilieu, neurons keep toxic calcium ions outside the cell butallow the cell membrane to transmit signals electrically. Ifchanges in the environment damage the membranes or if the energy-drivenpumps fail, calcium ions can enter the neuron and permanentlydisable it. Local oxygen deprivation, such as that which occursduring ischemic stroke, can lead rapidly to transient or permanentinjury of neurons by affecting the cells' energy requirements,pump function, . . . [Full Text of this Article]
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Dr. del Zoppo is an associate professor in the Department of Molecular and Experimental Medicine, the Scripps Research Institute, and a member of the Division of Hematology and Medical Oncology, Department of Medicine, Scripps Clinic — both in La Jolla, Calif.
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