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FOCUS ON RESEARCH Previous Volume 354:553-555 February 9, 2006 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Neurons are extremely sensitive cells, whose function, like that of all cells, can be influenced by changes in their environment. Using pumps to regulate the internal and external electrolyte milieu, neurons keep toxic calcium ions outside the cell but allow the cell membrane to transmit signals electrically. If changes in the environment damage the membranes or if the energy-driven pumps fail, calcium ions can enter the neuron and permanently disable it. Local oxygen deprivation, such as that which occurs during ischemic stroke, can lead rapidly to transient or permanent injury of neurons by affecting the cells' energy requirements, pump function, . . . [Full Text of this Article]

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Dr. del Zoppo is an associate professor in the Department of Molecular and Experimental Medicine, the Scripps Research Institute, and a member of the Division of Hematology and Medical Oncology, Department of Medicine, Scripps Clinic — both in La Jolla, Calif.

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